QuickView for ATR;jsessionid=0D086649655842F6C4694AA5739493D2 (gene)

Gene Symbol:

ATR Homo sapiens

Full name:

ATR serine/threonine kinase

Synonyms:

FCTCS, FRP1, MEC1, SCKL, SCKL1, serine/threonine-protein kinase ATR, FRAP-related protein-1, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3-related protein

Genomic Location:

Chr 3: 143650767-143780358

Description:

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also...

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The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  GGGCGGR_SP1_Q6 ,  SCGGAAGY_ELK1_02 ,  CTTTGT_LEF1_Q2

Cytogenetic Map:

3q23

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