QuickView for Abcb1 (gene)

Gene Symbol:

ABCB1 Homo sapiens

Full name:

ATP binding cassette subfamily B member 1

Synonyms:

ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, multidrug resistance protein 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, P glycoprotein, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance

Genomic Location:

Chr 7: 86970884-87180500

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/...

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  STAT4_01 ,  TATAAA_TATA_01 ,  TNCATNTCCYR_UNKNOWN ,  NKX62_Q2 ,  CTTTAAR_UNKNOWN ,  TTGTTT_FOXO4_01 ,  STAT5A_04

Cytogenetic Map:

7q21.12

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