QuickView for Abcg5 (gene)

Gene Symbol:

ABCG5 Homo sapiens

Full name:

ATP binding cassette subfamily G member 5

Synonyms:

STSL, ATP-binding cassette sub-family G member 5, ATP-binding cassette, sub-family G (WHITE), member 5, sterolin 1

Genomic Location:

Chr 2: 43893115-43919462

Description:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The pro...

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA3_01 ,  AP3_Q6 ,  GATA1_04 ,  LMO2COM_02 ,  IK2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-496

Cytogenetic Map:

2p21

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