QuickView for Aco2 (gene)

Gene Symbol:

ACO2 Homo sapiens

Full name:

aconitase 2

Synonyms:

ACONM, HEL-S-284, ICRD, OCA8, OPA9, aconitate hydratase, mitochondrial, aconitase 2, mitochondrial, citrate hydro-lyase, epididymis secretory sperm binding protein Li 284, mitochondrial aconitase

Genomic Location:

Chr 22: 40195075-40254939

Description:

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that...

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The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  E2F4DP1_01 ,  VDR_Q6 ,  TGACCTY_ERR1_Q2 ,  WHN_B ,  CATTTCA_MIR203 ,  E2F_Q6 ,  E2F1_Q6_01 ,  NKX62_Q2 ,  E2F_Q4 ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  HSF_Q6 ,  E2F1DP1_01 ,  RORA1_01 ,  SCGGAAGY_ELK1_02 ,  E2F_02 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  ERR1_Q2 ,  TGACCTTG_SF1_Q6 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-203

Cytogenetic Map:

22q13.2

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