QuickView for Add3 (gene)

Gene Symbol:

ADD3 Homo sapiens

Full name:

adducin 3

Synonyms:

ADDL, CPSQ3, gamma-adducin, adducin 3 (gamma), adducin-like protein 70

Genomic Location:

Chr 10: 111755716-111885313

Description:

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducin...

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Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  OCT1_07 ,  CMYB_01 ,  TFIIA_Q6 ,  GATA1_03 ,  HNF1_01 ,  GATA1_01 ,  MZF1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  P53_DECAMER_Q2 ,  YATTNATC_UNKNOWN ,  GGCACAT_MIR455 ,  AACTGGA_MIR145 ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  GGGCATT_MIR365 ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  MYCMAX_02 ,  LEF1_Q2 ,  TCTGATA_MIR361 ,  GCACCTT_MIR18A_MIR18B ,  TITF1_Q3 ,  CCTGTGA_MIR513 ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  CAGGTG_E12_Q6 ,  ATGTTAA_MIR302C ,  YKACATTT_UNKNOWN ,  CTTTAAR_UNKNOWN ,  GCM_Q2 ,  TGCCAAR_NF1_Q6 ,  RNGTGGGC_UNKNOWN ,  GFI1_01 ,  TTGCCAA_MIR182 ,  CHX10_01 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  AAAYRNCTG_UNKNOWN ,  YTAATTAA_LHX3_01 ,  RGAGGAARY_PU1_Q6 ,  SREBP_Q3 ,  CTGCAGY_UNKNOWN ,  TGCTTTG_MIR330 ,  GTGGGTGK_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  MMEF2_Q6 ,  AACTTT_UNKNOWN ,  DR4_Q2 ,  PPARA_02 ,  TCATCTC_MIR143 ,  ELF1_Q6 ,  RRCCGTTA_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  CCTNTMAGA_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

10q25.1-q25.2

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