QuickView for Adm (gene)

Gene Symbol:

ADM Homo sapiens

Full name:

adrenomedullin

Synonyms:

AM, PAMP, ADM, preproadrenomedullin, proadrenomedullin N-20 terminal peptide

Genomic Location:

Chr 11: 10283218-10285499

Description:

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antim...

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The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGANTCA_AP1_C ,  GATA1_03 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GATA_Q6 ,  YATGNWAAT_OCT_C ,  ZF5_01 ,  TACTTGA_MIR26A_MIR26B ,  GGGCATT_MIR365 ,  RFX1_01 ,  GATA1_04 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  RGAANNTTC_HSF1_01 ,  LFA1_Q6 ,  CEBP_01 ,  HNF4_Q6 ,  LMO2COM_02 ,  ACTWSNACTNY_UNKNOWN ,  POU3F2_02 ,  CHOP_01 ,  GTTATAT_MIR410 ,  AACTTT_UNKNOWN ,  DR4_Q2

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

11p15.4

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