QuickView for AdsA (gene)

Gene Symbol:

RNF170 Homo sapiens

Full name:

ring finger protein 170

Synonyms:

ADSA, SNAX1, E3 ubiquitin-protein ligase RNF170, RING-type E3 ubiquitin transferase RNF170, putative LAG1-interacting protein

Genomic Location:

Chr 8: 42829548-42870939

Description:

This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by t...

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This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGYGTGNY_UNKNOWN ,  TGCGCANK_UNKNOWN ,  YGCGYRCGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-26

Cytogenetic Map:

8p11.21

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