QuickView for Alpha-ketoglutarate-dependent dioxygenase AlkB-like (biogroup)

Description:: AlkB is a DNA repair enzyme that removes methyl adducts and some larger alkylation lesions from endocyclic positions on purine and pyrimidine bases. It is a dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. The catalytic core of AlkB is homologous to other Fe-2OG dioxygenases. Two discrete global conformations have been observed for AlkB, differing in accessibility of a putative oxygen-diffusion tunnel.

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