QuickView for Arhgef3 (gene)

Gene Symbol:

ARHGEF3 Homo sapiens

Full name:

Rho guanine nucleotide exchange factor 3

Synonyms:

GEF3, STA3, XPLN, rho guanine nucleotide exchange factor 3, 59.8 kDA protein, Rho guanine nucleotide exchange factor (GEF) 3, RhoGEF protein, exchange factor found in platelets and leukemic and neuronal tissues, XPLN

Genomic Location:

Chr 3: 56736486-56810993

Description:

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleot...

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Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGCACT_MIR5123P ,  STAT_Q6 ,  TTGGAGA_MIR5155P_MIR519E ,  CACCAGC_MIR138 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TTGCCAA_MIR182 ,  TGACATY_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182

miRNA binding sites
(Source: miRecords):

hsa-miR-373 Targeted Genes

Cytogenetic Map:

3p14.3

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