QuickView for Arrb2 (gene)
- Gene Symbol:
- ARRB2
Homo sapiens - Full name:
- arrestin beta 2
- Synonyms:
- ARB2, ARR2, BARR2, beta-arrestin-2, arrestin 3, non-visual arrestin-3
- Genomic Location:
- Chr 17: 4560538-4571544
- Description:
-
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor fun...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
GATTGGY_NFY_Q6_01 , GABP_B , ETS_Q4 , RYTTCCTG_ETS2_B , FOX_Q2 , TEL2_Q6 , GGGCATT_MIR365 , E2F1_Q4 , GGGAGGRR_MAZ_Q6 , DBP_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17p13.2
GO Molecular Function
structural molecule activity | alpha-1B adrenergic receptor binding | kinase binding | D1 dopamine receptor binding | 14-3-3 protein binding | protein kinase binding | type 1 angiotensin receptor binding | protein kinase B binding | enzyme binding | mitogen-activated protein kinase binding | protein-containing complex binding | signaling receptor binding | G-protein coupled serotonin receptor binding | adrenergic receptor binding | protein domain specific binding | type 2A serotonin receptor binding | ubiquitin-like protein ligase binding | dopamine receptor binding | identical protein binding | platelet activating factor receptor binding | angiotensin receptor binding | alpha-1A adrenergic receptor binding | protein binding | arrestin family protein binding | ubiquitin protein ligase binding | G-protein coupled receptor binding | protein-containing complex scaffold activity | follicle-stimulating hormone receptor binding
GO Biological Process
protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | negative regulation of G-protein coupled receptor protein signaling pathway | negative regulation of smooth muscle cell apoptotic process | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | brain development | positive regulation of striated muscle cell differentiation | regulation of interleukin-1 beta production | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | negative regulation of immune system process | detection of stimulus | positive regulation of cellular component organization | cell motility | developmental process involved in reproduction | ovarian follicle development | positive regulation of apoptotic process | proteolysis | regulation of localization | positive regulation of collagen metabolic process | positive regulation of striated muscle tissue development | gonad development | regulation of programmed cell death | regulation of cardiac muscle cell differentiation | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | negative regulation of cysteine-type endopeptidase activity | establishment of localization | regulation of immune system process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | excitatory postsynaptic potential | nervous system development | negative regulation of mitochondrion organization | negative regulation of protein phosphorylation | regulation of leukocyte mediated cytotoxicity | positive regulation of phosphate metabolic process | regulation of organelle organization | membrane organization | negative regulation of proteolysis | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | positive regulation of synaptic transmission | protein transport | negative regulation of signaling | chemical synaptic transmission | positive regulation of peptidyl-serine phosphorylation | walking behavior | reproductive system development | multicellular organismal reproductive process | negative regulation of innate immune response | regulation of striated muscle tissue development | macromolecule localization | hemostasis | negative regulation of apoptotic process | regulation of proteolysis | response to growth factor | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | positive regulation of epithelial cell apoptotic process | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | positive regulation of muscle cell differentiation | negative regulation of apoptotic signaling pathway | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | negative regulation of interleukin-1 production | regulation of apoptotic process | regulation of metabolic process | catabolic process | G-protein coupled receptor internalization | negative regulation of tumor necrosis factor production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of establishment of planar polarity | cellular component organization | protein deubiquitination | negative regulation of toll-like receptor signaling pathway | response to transforming growth factor beta | development of primary sexual characteristics | head development | positive regulation of synaptic transmission, dopaminergic | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | negative regulation of tumor necrosis factor superfamily cytokine production | regulation of receptor internalization | cellular nitrogen compound biosynthetic process | ovulation cycle | regulation of protein ubiquitination | sensory perception of temperature stimulus | development of primary female sexual characteristics | reproduction | cellular protein catabolic process | response to temperature stimulus | rhythmic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | protein modification process | modulation of chemical synaptic transmission | cellular biosynthetic process | Wnt signaling pathway, planar cell polarity pathway | macromolecule modification | cell-cell signaling | cell chemotaxis | cell surface receptor signaling pathway involved in cell-cell signaling | detection of temperature stimulus involved in sensory perception | blood coagulation | regulation of nucleic acid-templated transcription | regulation of membrane potential | negative regulation of NF-kappaB transcription factor activity | detection of abiotic stimulus | locomotion | negative regulation of neuron apoptotic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | Wnt signaling pathway | negative regulation of phosphate metabolic process | negative regulation of interleukin-6 production | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of toll-like receptor signaling pathway | regulation of peptidase activity | regulation of MAPK cascade | regulation of collagen biosynthetic process | positive regulation of muscle organ development | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | wound healing | regulation of receptor-mediated endocytosis | negative regulation of natural killer cell mediated cytotoxicity | positive regulation of receptor-mediated endocytosis | regulation of gene expression | platelet activation | regulation of postsynaptic membrane potential | organic substance transport | nervous system process | protein catabolic process | synaptic signaling | adult walking behavior | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | adult locomotory behavior | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | peptide transport | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of smooth muscle cell apoptotic process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of synaptic transmission, dopaminergic | negative regulation of binding | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | negative regulation of interleukin-12 production | biosynthetic process | negative regulation of protein kinase B signaling | locomotory behavior | sensory perception of pain | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of immune response | detection of temperature stimulus involved in sensory perception of pain | regulation of GTPase activity | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | regulation of tumor necrosis factor production | ovulation cycle process | regulation of mitochondrion organization | dopamine receptor signaling pathway | regulation of interleukin-1 production | regulation of muscle cell apoptotic process | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of neuron apoptotic process | receptor internalization | positive regulation of DNA biosynthetic process | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of androgen receptor signaling pathway | regulation of protein phosphorylation | regulation of RNA metabolic process | negative regulation of protein ubiquitination | positive regulation of transport | coagulation | proteasome-mediated ubiquitin-dependent protein catabolic process | negative adaptation of signaling pathway | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of cardiac muscle tissue development | follicle-stimulating hormone signaling pathway | protein ubiquitination | response to wounding | regulation of animal organ morphogenesis | import into cell | detection of stimulus involved in sensory perception | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of programmed cell death | amide transport | regulation of vesicle-mediated transport | negative regulation of muscle cell apoptotic process | endocytosis | behavior | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | positive regulation of ion transport | negative regulation of cellular protein metabolic process | gene expression | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | desensitization of G-protein coupled receptor protein signaling pathway | protein modification by small protein conjugation or removal | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of muscle tissue development | transcription, DNA-templated | cell activation | positive regulation of MAPK cascade | regulation of natural killer cell mediated cytotoxicity | desensitization of G-protein coupled receptor protein signaling pathway by arrestin | regulation of peptidyl-serine phosphorylation | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | adult behavior | negative regulation of protein metabolic process | sensory perception | positive regulation of cardiac muscle cell differentiation | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | regulation of endocytosis | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of receptor internalization | reproductive structure development | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | positive regulation of DNA metabolic process | developmental process | regulation of muscle cell differentiation | regulation of DNA biosynthetic process | regulation of calcium ion transport | cellular protein modification process | detection of temperature stimulus | negative regulation of interleukin-1 beta production | regulation of transport | receptor metabolic process | negative regulation of GTPase activity | heterocycle metabolic process | negative regulation of hydrolase activity | central nervous system development | positive regulation of metabolic process | regulation of natural killer cell mediated immunity | positive regulation of collagen biosynthetic process | cellular metabolic process | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | positive regulation of cardiac muscle tissue development | modification-dependent protein catabolic process | negative regulation of cell death | regulation of interleukin-6 production | chemotaxis | positive regulation of endocytosis | positive regulation of protein ubiquitination | regulation of cellular component organization | positive regulation of calcium ion transport | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell | synaptic membrane | cytoplasm | intracellular organelle | dendritic tree | cell projection | postsynaptic membrane | endomembrane system | neuron spine | postsynapse | plasma membrane | vesicle | postsynaptic density | clathrin-coated pit | asymmetric synapse | endosome | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | cell periphery | basolateral plasma membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane
