QuickView for Atp2a2 (gene)

Gene Symbol:

ATP2A2 Homo sapiens

Full name:

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Synonyms:

ATP2B, DAR, DD, SERCA2, sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATPase Ca++ transporting cardiac muscle slow twitch 2, ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2, SR Ca(2+)-ATPase 2, calcium pump 2, calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, cardiac Ca2+ ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase

Genomic Location:

Chr 12: 109203815-109273278

Description:

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxatio...

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This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  OCT1_05 ,  CGGAARNGGCNG_UNKNOWN ,  TFIIA_Q6 ,  MCAATNNNNNGCG_UNKNOWN ,  TGANTCA_AP1_C ,  DR3_Q4 ,  TGGNNNNNNKCCAR_UNKNOWN ,  FOX_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HFH3_01 ,  AML_Q6 ,  OCT_Q6 ,  YGTCCTTGR_UNKNOWN ,  NKX3A_01 ,  GCANCTGNY_MYOD_Q6 ,  AAAYWAACM_HFH4_01 ,  FOXD3_01 ,  HFH1_01 ,  TTTGTAG_MIR520D ,  YATTNATC_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  SRY_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ATGTACA_MIR493 ,  STAT6_01 ,  TAAYNRNNTCC_UNKNOWN ,  E2A_Q2 ,  OCT1_Q5_01 ,  EGR2_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  AML1_01 ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  OCT1_Q6 ,  PAX4_02 ,  RP58_01 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  SP1_Q4_01 ,  NKX62_Q2 ,  HNF3_Q6 ,  ZID_01 ,  FOXJ2_01 ,  STAT5A_03 ,  NFY_01 ,  E4F1_Q6 ,  NKX61_01 ,  TCCAGAT_MIR5165P ,  HFH4_01 ,  SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  AML1_Q6 ,  TTGCCAA_MIR182 ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GAGCCAG_MIR149 ,  SMAD4_Q6 ,  STAT5A_01 ,  SP1_Q6_01 ,  GCTNWTTGK_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  COREBINDINGFACTOR_Q6 ,  ACACTAC_MIR1423P ,  SP1_Q2_01 ,  TCCAGAG_MIR518C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

12q24.11

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