QuickView for B7-2 (gene)

Gene Symbol:

CD86 Homo sapiens

Full name:

CD86 molecule

Synonyms:

B7-2, B7.2, B70, CD28LG2, LAB72, T-lymphocyte activation antigen CD86, B-lymphocyte activation antigen B7-2, BU63, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CTLA-4 counter-receptor B7.2, FUN-1

Genomic Location:

Chr 3: 123256911-123322673

Description:

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal...

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This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  OCT1_B ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  OCT_Q6 ,  OCT1_Q5_01 ,  TGACCTY_ERR1_Q2 ,  NFKAPPAB65_01 ,  CEBP_01 ,  RNGTGGGC_UNKNOWN ,  IK2_01 ,  ARGGGTTAA_UNKNOWN ,  IK1_01 ,  CREL_01 ,  GGARNTKYCCA_UNKNOWN ,  NFKB_Q6 ,  GGGNNTTTCC_NFKB_Q6_01

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Cytogenetic Map:

3q13.33

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