QuickView for BACE1 (gene)

Gene Symbol:

BACE1 Homo sapiens

Full name:

beta-secretase 1

Synonyms:

ASP2, BACE, HSPC104, beta-secretase 1, APP beta-secretase, asp 2, aspartyl protease 2, beta-secretase 1 precursor variant 1, beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, beta-site amyloid beta A4 precursor protein-cleaving enzyme, memapsin-2, membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2

Genomic Location:

Chr 11: 116661624-116692182

Description:

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from...

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This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  TTTGCAC_MIR19A_MIR19B ,  AAGCCAT_MIR135A_MIR135B ,  CAGTGTT_MIR141_MIR200A ,  CTTTGA_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  LFA1_Q6 ,  CAGGTG_E12_Q6 ,  GTCTTCC_MIR7 ,  TGCCTTA_MIR124A ,  ACCAAAG_MIR9 ,  ACTAYRNNNCCCR_UNKNOWN ,  CCTGCTG_MIR214 ,  SCGGAAGY_ELK1_02 ,  TGACAGNY_MEIS1_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  AAGTCCA_MIR422B_MIR422A ,  TATTATA_MIR374 ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374

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miRNA binding sites
(Source: miRecords):

hsa-miR-107 Targeted Genes ,  hsa-miR-29a Targeted Genes ,  hsa-miR-29b Targeted Genes ,  hsa-miR-9 Targeted Genes

Cytogenetic Map:

11q23.3

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