QuickView for BCL11A (gene)

Gene Symbol:

BCL11A Homo sapiens

Full name:

B cell CLL/lymphoma 11A

Synonyms:

BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856, B-cell lymphoma/leukemia 11A, B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2, BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1, C2H2-type zinc finger protein, COUP-TF-interacting protein 1, ecotropic viral integration site 9 homolog, ecotropic viral integration site 9 protein homolog, zinc finger protein 856

Genomic Location:

Chr 2: 60531806-60634137

Description:

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regul...

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This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  CACTGTG_MIR128A_MIR128B ,  ATGCAGT_MIR217 ,  IRF1_01 ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  SMTTTTGT_UNKNOWN ,  GAGCCTG_MIR484 ,  TTTGCAG_MIR518A2 ,  HNF1_01 ,  CCCACAT_MIR2993P ,  AAGCCAT_MIR135A_MIR135B ,  GNCF_01 ,  MZF1_01 ,  FOXJ2_02 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  MYOGNF1_01 ,  ATGTCAC_MIR489 ,  SYATTGTG_UNKNOWN ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  NKX3A_01 ,  GCAAGGA_MIR502 ,  AAANWWTGC_UNKNOWN ,  HFH1_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CIZ_01 ,  EVI1_04 ,  IPF1_Q4 ,  HP1SITEFACTOR_Q6 ,  AREB6_04 ,  STAT6_01 ,  FAC1_01 ,  ZIC3_01 ,  GTGCAAA_MIR507 ,  TTAYRTAA_E4BP4_01 ,  CREB_Q3 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  ATAGGAA_MIR202 ,  GGGAGGRR_MAZ_Q6 ,  CREBP1_Q2 ,  TFIII_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  YY1_Q6 ,  CAGGTA_AREB6_01 ,  GTGACGY_E4F1_Q6 ,  FREAC3_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  CACCAGC_MIR138 ,  AP4_01 ,  NKX62_Q2 ,  GTTTGTT_MIR495 ,  ATGCTGC_MIR103_MIR107 ,  NF1_Q6 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  STAT5A_03 ,  CREBP1_01 ,  PITX2_Q2 ,  CEBPB_02 ,  HIF1_Q5 ,  AHR_Q5 ,  IRF_Q6 ,  RAAGNYNNCTTY_UNKNOWN ,  AAAGACA_MIR511 ,  SPZ1_01 ,  TGTTTGY_HNF3_Q6 ,  SOX5_01 ,  TAXCREB_02 ,  KCCGNSWTTT_UNKNOWN ,  ACTWSNACTNY_UNKNOWN ,  AHRARNT_01 ,  AHR_01 ,  HMGIY_Q6 ,  GTGCCTT_MIR506 ,  AATGTGA_MIR23A_MIR23B ,  TTGCCAA_MIR182 ,  FREAC2_01 ,  CEBP_Q3 ,  HAND1E47_01 ,  CCTGCTG_MIR214 ,  WGGAATGY_TEF1_Q6 ,  ATATGCA_MIR448 ,  CHOP_01 ,  CART1_01 ,  CAAGGAT_MIR362 ,  PIT1_Q6 ,  IK2_01 ,  RTTTNNNYTGGM_UNKNOWN ,  SREBP_Q3 ,  CTGCAGY_UNKNOWN ,  CTGYNNCTYTAA_UNKNOWN ,  GTGGGTGK_UNKNOWN ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  CACBINDINGPROTEIN_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  P300_01 ,  AAACCAC_MIR140 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  TGACATY_UNKNOWN ,  CRX_Q4 ,  ACCTGTTG_UNKNOWN ,  HNF1_Q6 ,  HIF1_Q3 ,  NFKB_C ,  CAATGCA_MIR33 ,  STTTCRNTTT_IRF_Q6 ,  HNF4_01_B ,  PAX4_01 ,  ACATATC_MIR190 ,  IRF2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-433-5p ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

2p16.1

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