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QuickView for BCL2L1 (gene)


Gene Symbol:
BCL2L1 Homo sapiens Homo sapiens
Full name:
BCL2 like 1
Synonyms:
BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52, bcl-2-like protein 1, apoptosis regulator Bcl-X, protein phosphatase 1, regulatory subunit 52
Genomic Location:
Chr 20: 29715922-29774317
Description:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitoch...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 20
20q11.21





GO Molecular Function

kinase binding | protein kinase binding | enzyme binding | protein domain specific binding | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | death domain binding | BH3 domain binding | protein dimerization activity | BH domain binding

GO Biological Process

response to radiation | negative regulation of execution phase of apoptosis | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | response to virus | release of cytochrome c from mitochondria | response to cytokine | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | ovarian follicle development | positive regulation of apoptotic process | regulation of localization | gonad development | regulation of programmed cell death | female gonad development | response to cycloheximide | epithelial cell apoptotic process | establishment of localization | neuron death | negative regulation of neuron death | negative regulation of cellular process | regulation of protein localization to membrane | cell differentiation | male gamete generation | positive regulation of intrinsic apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of mitochondrion organization | response to drug | cell part morphogenesis | regulation of organelle organization | membrane organization | response to antibiotic | regulation of neuron death | cellular process | localization | extrinsic apoptotic signaling pathway | regulation of mitochondrial membrane potential | negative regulation of signaling | negative regulation of protein localization to plasma membrane | reproductive system development | multicellular organismal reproductive process | negative regulation of apoptotic process | regulation of cell cycle | negative regulation of release of cytochrome c from mitochondria | gamete generation | interspecies interaction between organisms | intrinsic apoptotic signaling pathway | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | cellular response to organonitrogen compound | cellular component organization | regulation of cell division | development of primary sexual characteristics | mitochondrion morphogenesis | response to stimulus | regulation of cellular protein localization | modulation by virus of host process | response to stress | germ cell development | regulation of cell proliferation | programmed cell death | development of primary female sexual characteristics | reproduction | response to alcohol | apoptotic mitochondrial changes | embryo development | mitochondrion organization | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | apoptotic process in bone marrow | regulation of membrane potential | regulation of cellular response to stress | response to nitrogen compound | negative regulation of neuron apoptotic process | apoptotic process | response to external biotic stimulus | system development | reproductive process | regulation of signal transduction | multicellular organism development | response to amino acid | cellular response to DNA damage stimulus | regulation of intrinsic apoptotic signaling pathway | negative regulation of cellular protein localization | cellular process regulating host cell cycle in response to virus | regulation of extrinsic apoptotic signaling pathway | regulation of mitochondrial membrane permeability | response to ketone | cellular response to stress | cell cycle | suppression by virus of host apoptotic process | modification of morphology or physiology of other organism | cellular response to radiation | mitochondrial transport | neuron apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | cellular response to alkaloid | cellular response to gamma radiation | negative regulation of extrinsic apoptotic signaling pathway | cellular response to cytokine stimulus | cell proliferation | fertilization | hepatocyte apoptotic process | response to toxic substance | regulation of apoptotic signaling pathway | cellular response to amino acid stimulus | response to gamma radiation | regulation of mitochondrion organization | mitochondrial membrane organization | chordate embryonic development | cell communication | regulation of cytokinesis | regulation of neuron apoptotic process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of signal transduction | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | viral process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | cellular response to virus | apoptotic signaling pathway | regulation of mitotic cell cycle | multicellular organism reproduction | development of primary male sexual characteristics | regulation of growth | response to organic substance | male sex differentiation | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | regulation of protein localization to plasma membrane | negative regulation of programmed cell death | male gonad development | negative regulation of mitotic cell cycle | endocytosis | positive regulation of cell death | regulation of response to DNA damage stimulus | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | cell death | animal organ development | positive regulation of programmed cell death | cellular response to ionizing radiation | response to alkaloid | negative regulation of cell cycle | response to fungicide | regulation of cell communication | regulation of membrane permeability | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | response to organic cyclic compound | cell development | extrinsic apoptotic signaling pathway in absence of ligand | anatomical structure morphogenesis | response to biotic stimulus | reproductive structure development | developmental process | organelle organization | spermatogenesis | modulation by virus of host morphology or physiology | response to organonitrogen compound | in utero embryonic development | regulation of execution phase of apoptosis | mitotic cell cycle checkpoint | female sex differentiation | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | cell cycle checkpoint | negative regulation of cell death | sexual reproduction | regulation of cellular component organization | response to ionizing radiation | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation by symbiont of host apoptotic process | multicellular organismal process

GO Cellular Component

mitochondrial matrix | exocytic vesicle | integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | synapse | mitochondrial inner membrane | organelle membrane | microtubule organizing center | nuclear membrane | cytoplasmic vesicle | cell | organelle outer membrane | intrinsic component of membrane | transport vesicle membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | presynapse | centrosome | protein-containing complex | secretory vesicle | endomembrane system | nuclear envelope | exocytic vesicle membrane | vesicle | transport vesicle | microtubule cytoskeleton | mitochondrion | synaptic vesicle | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | vesicle membrane | mitochondrial envelope | membrane-enclosed lumen | outer membrane | synaptic vesicle membrane | mitochondrial membrane | cytosol | intracellular vesicle | cytoskeleton | Bcl-2 family protein complex | intracellular | cell junction | membrane | cytoplasmic vesicle membrane