QuickView for BCL2L2;jsessionid=BA73F72F2798719D03B638359CCC87C2 (gene)

Gene Symbol:

BCL2L2 Homo sapiens

Full name:

BCL2 like 2

Synonyms:

BCL-W, BCL2-L-2, BCLW, PPP1R51, bcl-2-like protein 2, apoptosis regulator BCL-W, protein phosphatase 1, regulatory subunit 51

Genomic Location:

Chr 14: 22845852-22850808

Description:

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF-...

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This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  EFC_Q6 ,  AP3_Q6 ,  HEN1_01 ,  GAGACTG_MIR452 ,  GGGACCA_MIR133A_MIR133B ,  ZIC3_01 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TCTAGAG_MIR517 ,  TFIII_Q6 ,  AP4_Q6 ,  ETS2_B ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  TAGAACC_MIR182 ,  OCT1_03 ,  AAGWWRNYGGC_UNKNOWN ,  HMX1_01 ,  TAATAAT_MIR126 ,  SP1_Q6 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  GAGCCAG_MIR149 ,  HEN1_02 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  CTGAGCC_MIR24 ,  PAX_Q6 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CTCTAGA_MIR526C_MIR518F_MIR526A ,  CAGCTG_AP4_Q5 ,  SP1_Q6_01 ,  AAACCAC_MIR140 ,  PAX4_03 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ETS1_B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-29

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Cytogenetic Map:

14q11.2

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