QuickView for BH3-only (gene)
- Gene Symbol:
- Bbc3
Mus musculus - Full name:
- BCL2 binding component 3
- Synonyms:
- PUMA, PUMA/JFY1, bcl-2-binding component 3, BH3-only, Bcl-2 binding component 3, p53 up-regulated modulator of apoptosis
- Genomic Location:
- Chr 7: 16894987-16903683
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
GO Molecular Function
enzyme binding | ATPase binding | protein binding
GO Biological Process
response to radiation | regulation of cysteine-type endopeptidase activity | response to endoplasmic reticulum stress | release of cytochrome c from mitochondria | positive regulation of cellular component organization | regulation of cellular localization | intracellular signal transduction | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | cytosolic calcium ion transport | regulation of localization | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | regulation of protein localization to membrane | positive regulation of intrinsic apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to DNA damage | cellular chemical homeostasis | regulation of protein oligomerization | regulation of organelle organization | membrane organization | regulation of neuron death | cellular process | localization | cellular homeostasis | metal ion transport | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | positive regulation of release of cytochrome c from mitochondria | regulation of proteolysis | positive regulation of T cell apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | intrinsic apoptotic signaling pathway | regulation of lymphocyte apoptotic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | cellular component organization | calcium ion homeostasis | calcium ion transport into cytosol | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | positive regulation of cellular protein localization | toxin transport | positive regulation of cysteine-type endopeptidase activity | execution phase of apoptosis | positive regulation of thymocyte apoptotic process | programmed cell death | cellular localization | divalent metal ion transport | positive regulation of proteolysis | apoptotic mitochondrial changes | mitochondrion organization | metal ion homeostasis | positive regulation of mitochondrion organization | apoptotic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | multicellular organism development | regulation of peptidase activity | calcium ion transmembrane transport | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of intrinsic apoptotic signaling pathway | ion transmembrane transport | negative regulation of endoplasmic reticulum calcium ion concentration | regulation of mitochondrial membrane permeability | cellular response to stress | positive regulation of cellular metabolic process | cellular ion homeostasis | cellular response to radiation | mitochondrial transport | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | positive regulation of hydrolase activity | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | positive regulation of neuron death | positive regulation of leukocyte apoptotic process | regulation of apoptotic signaling pathway | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of mitochondrion organization | mitochondrial membrane organization | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | regulation of T cell apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of establishment of protein localization | positive regulation of transport | negative regulation of cell growth | apoptotic signaling pathway | positive regulation of molecular function | release of sequestered calcium ion into cytosol | cation transmembrane transport | regulation of protein homooligomerization | regulation of establishment of protein localization | regulation of growth | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of thymocyte apoptotic process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | calcium ion transport | positive regulation of cell death | positive regulation of cellular component biogenesis | regulation of sequestering of calcium ion | cell death | positive regulation of programmed cell death | ion homeostasis | cellular response to ionizing radiation | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | inorganic cation transmembrane transport | intrinsic apoptotic signaling pathway by p53 class mediator | positive regulation of lymphocyte apoptotic process | multicellular organism aging | regulation of cell communication | regulation of membrane permeability | transmembrane transport | signaling | positive regulation of protein homooligomerization | determination of adult lifespan | regulation of endopeptidase activity | cation transport | endoplasmic reticulum calcium ion homeostasis | developmental process | organelle organization | regulation of cell growth | regulation of transport | positive regulation of protein oligomerization | cellular metal ion homeostasis | positive regulation of metabolic process | ion transport | regulation of protein localization | regulation of cell death | signal transduction by p53 class mediator | aging | divalent inorganic cation homeostasis | regulation of cellular component organization | response to ionizing radiation | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vacuole | mitochondrion | lytic vacuole | membrane-bounded organelle | organelle | mitochondrial envelope | lysosome | intracellular
