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QuickView for BPI;jsessionid=3D9F0F4A031D159EDBB609C1C92542EC (gene)


Gene Symbol:
BPI Homo sapiens Homo sapiens
Full name:
bactericidal/permeability-increasing protein
Synonyms:
BPIFD1, rBPI, bactericidal permeability-increasing protein, BPI fold containing family D, member 1, CAP 57, recombinant BPI holoprotein, rBPI
Genomic Location:
Chr 20: 36365966-36399319
Description:
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 20
20q11.23





GO Molecular Function

lipid binding | carbohydrate derivative binding | lipopolysaccharide binding

GO Biological Process

negative regulation of leukocyte activation | negative regulation of immune system process | exocytosis | neutrophil activation | defense response to other organism | establishment of localization | regulation of immune system process | negative regulation of cellular process | defense response | defense response to Gram-negative bacterium | cellular process | secretion | leukocyte degranulation | localization | regulation of cellular process | leukocyte activation | negative regulation of tumor necrosis factor production | response to stimulus | neutrophil degranulation | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | leukocyte activation involved in immune response | secretion by cell | negative regulation of macrophage activation | response to external biotic stimulus | negative regulation of interleukin-6 production | leukocyte mediated immunity | negative regulation of cytokine production | vesicle-mediated transport | regulated exocytosis | regulation of tumor necrosis factor production | regulation of macrophage activation | response to bacterium | negative regulation of cell activation | humoral immune response | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | defense response to bacterium | antimicrobial humoral response | immune response | regulation of cell activation | negative regulation of interleukin-8 production | cell activation | regulation of cytokine production | response to biotic stimulus | neutrophil mediated immunity | immune system process | regulation of interleukin-6 production | response to other organism

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vacuole | vesicle | extracellular exosome | specific granule | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | specific granule lumen | organelle | lysosome | extracellular space | membrane-enclosed lumen | azurophil granule | secretory granule lumen | intracellular vesicle | intracellular | membrane | vesicle lumen