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QuickView for BRAF (gene)


Gene Symbol:
BRAF Homo sapiens Homo sapiens
Full name:
B-Raf proto-oncogene, serine/threonine kinase
Synonyms:
B-RAF1, B-raf, BRAF1, NS7, RAFB1, serine/threonine-protein kinase B-raf, 94 kDa B-raf protein, B-Raf proto-oncogene serine/threonine-protein kinase (p94), B-Raf serine/threonine-protein, murine sarcoma viral (v-raf) oncogene homolog B1, proto-oncogene B-Raf, v-raf murine sarcoma viral oncogene homolog B, v-raf murine sarcoma viral oncogene homolog B1
Genomic Location:
Chr 7: 140080751-140271033
Description:
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q34





GO Molecular Function

GTPase binding | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | small GTPase binding | calcium ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | intracellular signal transduction | regulation of localization | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | regulation of MAP kinase activity | response to metal ion | positive regulation of phosphate metabolic process | cellular process | disaccharide metabolic process | localization | positive regulation of peptidyl-serine phosphorylation | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of cellular process | regulation of apoptotic process | trehalose metabolism in response to stress | regulation of metabolic process | positive regulation of cellular protein metabolic process | MAPK cascade | cellular response to metal ion | response to stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | protein serine/threonine kinase activity | cellular response to inorganic substance | cellular localization | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | activation of protein kinase activity | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | protein localization to membrane | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | cellular carbohydrate metabolic process | positive regulation of intracellular signal transduction | positive regulation of glucose transmembrane transport | regulation of cellular protein metabolic process | phosphorylation | carbohydrate metabolic process | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | activation of MAPKK activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | positive regulation of transport | trehalose metabolic process | oligosaccharide metabolic process | positive regulation of molecular function | establishment of protein localization to membrane | protein metabolic process | positive regulation of protein modification process | cellular response to calcium ion | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | metabolic process | negative regulation of programmed cell death | cellular protein localization | protein kinase activity | organic substance metabolic process | regulation of glucose transmembrane transport | animal organ development | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of MAPK cascade | regulation of peptidyl-serine phosphorylation | regulation of cell communication | signaling | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of MAP kinase activity | kinase activity | developmental process | cellular protein modification process | regulation of transport | response to calcium ion | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane