QuickView for BRD4 (gene)

Gene Symbol:

BRD4 Homo sapiens

Full name:

bromodomain containing 4

Synonyms:

CAP, HUNK1, HUNKI, MCAP, bromodomain-containing protein 4, chromosome-associated protein

Genomic Location:

Chr 19: 15209301-15252262

Description:

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromo...

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The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  TAL1ALPHAE47_01 ,  MZF1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AAAGGGA_MIR204_MIR211 ,  GCANCTGNY_MYOD_Q6 ,  GTGCAAA_MIR507 ,  HEB_Q6 ,  TAL1BETAE47_01 ,  GGATTA_PITX2_Q2 ,  TGCCTTA_MIR124A ,  ACCAAAG_MIR9 ,  ACTGCCT_MIR34B ,  TCCAGAT_MIR5165P ,  GGCAGCT_MIR22 ,  AP2REP_01 ,  AP4_Q6_01 ,  STAT5A_04 ,  WWTAAGGC_UNKNOWN ,  TAL1BETAITF2_01 ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-491

Cytogenetic Map:

19p13.12

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