QuickView for BRD8;jsessionid=A9D0E827D4A1256BD195CC17522BBA0E (gene)
- Gene Symbol:
- BRD8
Homo sapiens - Full name:
- bromodomain containing 8
- Synonyms:
- SMAP, SMAP2, p120, bromodomain-containing protein 8, skeletal muscle abundant protein 2, thyroid hormone receptor coactivating protein of 120 kDa, trCP120
- Genomic Location:
- Chr 5: 137503358-137542257
- Description:
-
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isofo...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q31.2
GO Molecular Function
RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | signaling receptor activity | DNA-binding transcription factor activity | thyroid hormone receptor activity
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | peptidyl-amino acid modification | RNA polymerase II transcription factor activity, sequence-specific DNA binding | histone modification | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | chromatin organization | transcription factor activity, direct ligand regulated sequence-specific DNA binding | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | histone H4 acetylation | response to stimulus | cellular nitrogen compound biosynthetic process | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | protein acetylation | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | histone H2A acetylation | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | protein metabolic process | DNA-binding transcription factor activity | regulation of growth | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | intracellular receptor signaling pathway | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | internal protein amino acid acetylation | cellular protein metabolic process | cellular macromolecule biosynthetic process | organelle organization | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | thyroid hormone receptor activity | signal transduction | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | histone acetyltransferase complex | cytoplasm | H4/H2A histone acetyltransferase complex | intracellular organelle | Swr1 complex | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | transferase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | SWI/SNF superfamily-type complex | membrane-enclosed lumen | protein acetyltransferase complex | nuclear chromatin | ATPase complex | intracellular | NuA4 histone acetyltransferase complex
