Bax inhibitor 1-related QuickView

Description:: Bax inhibitor-1 (BI-1) is a suppressor of apoptosis that interacts with BCL2 and BCL-X. Human Bax BI-1 is an evolutionarily conserved integral membrane protein containingmultiple membrane-spanning segments predominantly localised to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest this function. As plant BI-1 appears to localise predominantly to the ER, it was suggested that plant BI-1 could also regulate cell death triggered by ER stress.BI-1 appears to exert its effect through an interaction with calmodulin. This entry represents BI-1 and related sequences, including lifeguard proteins, which also act as apoptotic regulators.

QuickView for Bax inhibitor 1-related (biogroup)