QuickView for Bax (gene)
- Gene Symbol:
- BAX
Homo sapiens - Full name:
- BCL2 associated X, apoptosis regulator
- Synonyms:
- BCL2L4, apoptosis regulator BAX, BCL2 associated X protein, BCL2-associated X protein omega, Baxdelta2G9, Baxdelta2G9omega, Baxdelta2omega, bcl-2-like protein 4, bcl2-L-4
- Genomic Location:
- Chr 19: 54149929-54156867
- Description:
-
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, a...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Danio rerio , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
USF_Q6 , TCANNTGAY_SREBP1_01 , MYCMAX_03 , CACGTG_MYC_Q2 , MAX_01 , ARNT_02 , SREBP1_01 , LFA1_Q6 , MGGAAGTG_GABP_B , USF_01
- Cytogenetic Map:
-
19q13.33
GO Molecular Function
passive transmembrane transporter activity | transmembrane transporter activity | lipid binding | chaperone binding | protein domain specific binding | Hsp70 protein binding | transporter activity | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | death domain binding | BH3 domain binding | protein dimerization activity | channel activity | BH domain binding | heat shock protein binding
GO Biological Process
positive regulation of immune response | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | RNA metabolic process | positive regulation of endoplasmic reticulum unfolded protein response | positive regulation of release of sequestered calcium ion into cytosol | transcription by RNA polymerase II | leukocyte homeostasis | negative regulation of phosphorylation | brain development | limb development | protein homooligomerization | DNA-templated transcription, initiation | response to radiation | regulation of IRE1-mediated unfolded protein response | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | regulation of cysteine-type endopeptidase activity | positive regulation of IRE1-mediated unfolded protein response | response to endoplasmic reticulum stress | release of cytochrome c from mitochondria | positive regulation of cellular component organization | cell motility | mitochondrial outer membrane permeabilization | immune response-regulating signaling pathway | glycosphingolipid metabolic process | regulation of endoplasmic reticulum unfolded protein response | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | ovarian follicle development | positive regulation of apoptotic process | homeostasis of number of cells within a tissue | protein localization to mitochondrion | regulation of localization | regulation of cell cycle G1/S phase transition | organelle fusion | gonad development | regulation of programmed cell death | regulation of mitochondrial membrane permeability involved in apoptotic process | female gonad development | release of matrix enzymes from mitochondria | eye development | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | B cell receptor apoptotic signaling pathway | neuron death | negative regulation of neuron death | neuron migration | negative regulation of cellular process | membrane fusion | positive regulation of developmental process | positive regulation of mitochondrial membrane permeability involved in apoptotic process | embryonic appendage morphogenesis | cell differentiation | immune response-activating cell surface receptor signaling pathway | male gamete generation | positive regulation of intrinsic apoptotic signaling pathway | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | neurogenesis | regulation of protein oligomerization | post-embryonic animal organ morphogenesis | regulation of organelle organization | generation of neurons | membrane organization | B cell differentiation | tissue homeostasis | blood vessel morphogenesis | regulation of neuron death | cellular process | lymphocyte differentiation | localization | mitochondrial fragmentation involved in apoptotic process | cellular homeostasis | extrinsic apoptotic signaling pathway | limb morphogenesis | mitotic DNA integrity checkpoint | odontogenesis | mitochondrial fusion | tissue remodeling | passive transmembrane transporter activity | regulation of mitochondrial membrane potential | negative regulation of signaling | negative regulation of peptidyl-serine phosphorylation | negative regulation of G1/S transition of mitotic cell cycle | reproductive system development | programmed necrotic cell death | establishment of protein localization to mitochondrion | immune system development | establishment or maintenance of transmembrane electrochemical gradient | multicellular organismal reproductive process | macromolecule localization | negative regulation of apoptotic process | sphingolipid metabolic process | positive regulation of release of cytochrome c from mitochondria | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | diencephalon development | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | gamete generation | interspecies interaction between organisms | anatomical structure homeostasis | intrinsic apoptotic signaling pathway | regulation of lymphocyte apoptotic process | B cell negative selection | negative regulation of apoptotic signaling pathway | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | cellular lipid metabolic process | cellular response to topologically incorrect protein | calcium ion homeostasis | urogenital system development | T cell activation | development of primary sexual characteristics | response to UV | head development | mitochondrion morphogenesis | response to stimulus | vasculature development | embryonic limb morphogenesis | regulation of mitotic cell cycle phase transition | blood vessel remodeling | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | mononuclear cell proliferation | response to salt stress | cellular response to light stimulus | response to stress | positive regulation of cation transmembrane transport | hypothalamus development | germ cell development | regulation of response to endoplasmic reticulum stress | cellular nitrogen compound biosynthetic process | post-embryonic camera-type eye development | regulation of cell proliferation | multicellular organismal homeostasis | Sertoli cell proliferation | regulation of mammary gland epithelial cell proliferation | tube morphogenesis | positive regulation of cysteine-type endopeptidase activity | regulation of cell cycle phase transition | regulation of protein homodimerization activity | programmed cell death | development of primary female sexual characteristics | regulation of developmental pigmentation | reproduction | cellular localization | cardiovascular system development | positive regulation of mammary gland involution | positive regulation of proteolysis | cellular nitrogen compound metabolic process | positive regulation of apoptotic DNA fragmentation | immune response-activating signal transduction | extrinsic apoptotic signaling pathway via death domain receptors | apoptotic mitochondrial changes | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | negative regulation of metabolic process | spermatid differentiation | hemopoiesis | cellular component assembly | cellular biosynthetic process | kidney development | embryo development | mitochondrion organization | B cell receptor signaling pathway | positive regulation of membrane permeability | metal ion homeostasis | positive regulation of mitochondrion organization | blood vessel development | myeloid cell homeostasis | regulation of membrane potential | leukocyte differentiation | regulation of cellular response to stress | locomotion | negative regulation of neuron apoptotic process | apoptotic process | positive regulation of DNA catabolic process | regulation of calcium ion transport into cytosol | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | post-embryonic animal organ development | negative regulation of phosphate metabolic process | positive regulation of calcium ion transmembrane transport | mitotic DNA damage checkpoint | multicellular organism development | cell migration | regulation of peptidase activity | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cellular response to DNA damage stimulus | protein complex oligomerization | B cell apoptotic process | regulation of catalytic activity | lipid metabolic process | vagina development | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | ion transmembrane transport | post-embryonic camera-type eye morphogenesis | telencephalon development | negative regulation of endoplasmic reticulum calcium ion concentration | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of extrinsic apoptotic signaling pathway | protein localization to membrane | regulation of mitochondrial membrane permeability | cellular response to stress | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | cellular ion homeostasis | response to axon injury | cellular response to radiation | animal organ morphogenesis | mitochondrial transport | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | neuron apoptotic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | post-embryonic animal morphogenesis | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | B cell homeostasis | protein localization to organelle | negative regulation of binding | positive regulation of hydrolase activity | regulation of release of sequestered calcium ion into cytosol | homeostasis of number of cells | glycolipid metabolic process | T cell apoptotic process | B cell activation | cell proliferation | leukocyte proliferation | biosynthetic process | response to osmotic stress | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | fertilization | protein insertion into membrane | positive regulation of endopeptidase activity | positive regulation of B cell apoptotic process | regulation of calcium ion transmembrane transport | positive regulation of neuron death | response to toxic substance | positive regulation of leukocyte apoptotic process | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | programmed cell death involved in cell development | response to gamma radiation | regulation of apoptotic DNA fragmentation | post-embryonic development | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to UV | sensory organ development | regulation of B cell apoptotic process | regulation of mitochondrion organization | mitotic G1 DNA damage checkpoint | mitochondrial membrane organization | cellular cation homeostasis | positive regulation of extrinsic apoptotic signaling pathway | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | mitochondrial outer membrane permeabilization involved in programmed cell death | eye morphogenesis | female genitalia development | regulation of neuron apoptotic process | lymphocyte homeostasis | odontogenesis of dentin-containing tooth | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | apoptotic process involved in development | homeostatic process | limbic system development | regulation of protein phosphorylation | post-embryonic eye morphogenesis | renal system development | positive regulation of transport | genitalia development | viral process | cerebral cortex development | apoptotic signaling pathway | positive regulation of apoptotic process involved in development | embryonic morphogenesis | regulation of mitotic cell cycle | lymphocyte activation | positive regulation of molecular function | positive regulation of cell cycle arrest | establishment of protein localization to membrane | regulation of nitrogen utilization | multicellular organism reproduction | positive regulation of execution phase of apoptosis | protein-containing complex assembly | development of primary male sexual characteristics | activation of immune response | regulation of fibroblast proliferation | response to organic substance | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | G1 DNA damage checkpoint | retina development in camera-type eye | epithelial cell proliferation | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | establishment of protein localization to organelle | anatomical structure development | regulation of protein heterodimerization activity | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | membrane lipid metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of programmed cell death | male gonad development | development of secondary sexual characteristics | negative regulation of mitotic cell cycle | cellular protein localization | retinal cell programmed cell death | regulation of tissue remodeling | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | positive regulation of cell death | nucleobase-containing compound metabolic process | positive regulation of mitochondrial membrane permeability | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of sequestering of calcium ion | cell death | animal organ development | positive regulation of ion transport | forebrain development | pallium development | negative regulation of cellular protein metabolic process | T cell proliferation | gene expression | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | ion homeostasis | regulation of phosphate metabolic process | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | intrinsic apoptotic signaling pathway by p53 class mediator | establishment of protein localization | T cell homeostasis | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | cell activation | positive regulation of lymphocyte apoptotic process | camera-type eye development | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | negative regulation of protein metabolic process | positive regulation of developmental pigmentation | protein insertion into mitochondrial membrane | lymphocyte proliferation | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of membrane permeability | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | regulation of protein binding | cell development | embryonic digit morphogenesis | protein localization | regulation of epithelial cell proliferation | negative regulation of fibroblast proliferation | extrinsic apoptotic signaling pathway in absence of ligand | response to unfolded protein | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | cellular macromolecule biosynthetic process | channel activity | camera-type eye morphogenesis | positive regulation of calcium ion transport into cytosol | T cell homeostatic proliferation | signal transduction involved in DNA damage checkpoint | positive regulation of tissue remodeling | reproductive structure development | regulation of developmental process | regulation of ion transport | endoplasmic reticulum calcium ion homeostasis | positive regulation of DNA metabolic process | developmental process | organelle organization | positive regulation of cell cycle process | regulation of calcium ion transport | spermatogenesis | B cell proliferation | mitotic G1/S transition checkpoint | tube development | carbohydrate derivative metabolic process | regulation of transport | positive regulation of protein oligomerization | necrotic cell death | negative regulation of cell proliferation | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c | cellular metal ion homeostasis | heterocycle metabolic process | regulation of apoptotic process involved in development | signal transduction involved in mitotic G1 DNA damage checkpoint | central nervous system development | positive regulation of metabolic process | positive regulation of apoptotic process involved in mammary gland involution | regulation of execution phase of apoptosis | apoptotic process involved in morphogenesis | ion transport | thymocyte apoptotic process | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | female sex differentiation | positive regulation of apoptotic process involved in morphogenesis | cellular response to organic substance | regulation of cell death | sex differentiation | ectopic germ cell programmed cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | circulatory system development | apoptotic process involved in embryonic digit morphogenesis | divalent inorganic cation homeostasis | sexual reproduction | regulation of cellular component organization | positive regulation of calcium ion transport | response to ionizing radiation | positive regulation of apoptotic signaling pathway | positive regulation of signaling | apoptotic process involved in blood vessel morphogenesis | signal transduction | regulation of signaling | macromolecule metabolic process | B cell homeostatic proliferation | positive regulation of response to endoplasmic reticulum stress | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | mitochondrial permeability transition pore complex | endomembrane system | endoplasmic reticulum membrane | nuclear envelope | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | extracellular space | cell periphery | pore complex | outer membrane | mitochondrial membrane | BAX complex | cytosol | Bcl-2 family protein complex | intracellular | membrane
