QuickView for Bub1 (gene)
- Gene Symbol:
- BUB1
Homo sapiens - Full name:
- BUB1 mitotic checkpoint serine/threonine kinase
- Synonyms:
- BUB1A, BUB1L, hBUB1, mitotic checkpoint serine/threonine-protein kinase BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog, budding uninhibited by benzimidazoles 1 homolog, mitotic spindle checkpoint kinase, putative serine/threonine-protein kinase
- Genomic Location:
- Chr 2: 111111881-111152135
- Description:
-
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may a...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
2q13
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of cell cycle process | negative regulation of cellular process | regulation of organelle organization | regulation of chromosome segregation | cellular process | regulation of mitotic nuclear division | regulation of chromosome separation | negative regulation of chromosome segregation | regulation of cell cycle | interspecies interaction between organisms | negative regulation of mitotic metaphase/anaphase transition | spindle checkpoint | regulation of cellular process | cellular component organization | regulation of mitotic cell cycle phase transition | chromosome segregation | regulation of cell cycle phase transition | protein serine/threonine kinase activity | programmed cell death | reproduction | protein modification process | macromolecule modification | meiotic chromosome segregation | apoptotic process | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | sister chromatid segregation | phosphorus metabolic process | cell cycle | regulation of mitotic sister chromatid separation | negative regulation of mitotic nuclear division | cell proliferation | cell division | phosphorylation | meiosis II | mitotic spindle assembly checkpoint | protein phosphorylation | phosphate-containing compound metabolic process | nuclear chromosome segregation | negative regulation of mitotic sister chromatid segregation | negative regulation of mitotic sister chromatid separation | viral process | regulation of mitotic cell cycle | regulation of sister chromatid cohesion | meiotic sister chromatid cohesion, centromeric | meiotic sister chromatid segregation | protein metabolic process | regulation of sister chromatid segregation | mitotic cell cycle | nuclear division | metabolic process | negative regulation of mitotic cell cycle | protein kinase activity | organic substance metabolic process | cell death | regulation of chromosome organization | chromosome organization involved in meiotic cell cycle | negative regulation of cell cycle | regulation of mitotic sister chromatid segregation | meiotic cell cycle | negative regulation of chromosome organization | meiotic sister chromatid cohesion | cellular protein metabolic process | kinase activity | organelle organization | sister chromatid cohesion | cellular protein modification process | regulation of mitotic metaphase/anaphase transition | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cell cycle checkpoint | regulation of cellular component organization | macromolecule metabolic process
GO Cellular Component
condensed nuclear chromosome | chromosome | intracellular membrane-bounded organelle | condensed nuclear chromosome kinetochore | chromosome, centromeric region | condensed chromosome outer kinetochore | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | condensed nuclear chromosome, centromeric region | nuclear chromosome | condensed chromosome kinetochore | membrane-bounded organelle | condensed nuclear chromosome outer kinetochore | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | membrane | condensed chromosome
