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QuickView for Bub3 (gene)


Gene Symbol:
BUB3 Homo sapiens Homo sapiens
Full name:
BUB3, mitotic checkpoint protein
Synonyms:
BUB3L, hBUB3, mitotic checkpoint protein BUB3, BUB3 budding uninhibited by benzimidazoles 3 homolog, budding uninhibited by benomyl, budding uninhibited by benzimidazoles 3 homolog, mitotic checkpoint component, testicular tissue protein Li 27
Genomic Location:
Chr 10: 124903860-124914871
Description:
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q26.13


Transcripts Names
NM_001007793
NM_004725



GO Molecular Function

ubiquitin binding | ubiquitin-like protein binding | protein binding

GO Biological Process

regulation of cell cycle process | proteolysis | negative regulation of cellular process | regulation of organelle organization | regulation of chromosome segregation | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of mitotic nuclear division | regulation of chromosome separation | negative regulation of chromosome segregation | regulation of cell cycle | negative regulation of mitotic metaphase/anaphase transition | spindle checkpoint | regulation of cellular process | catabolic process | cellular component organization | regulation of mitotic cell cycle phase transition | chromosome segregation | anaphase-promoting complex-dependent catabolic process | regulation of cell cycle phase transition | reproduction | cellular protein catabolic process | proteasomal protein catabolic process | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | sister chromatid segregation | cell cycle | protein catabolic process | regulation of mitotic sister chromatid separation | negative regulation of mitotic nuclear division | cell division | mitotic spindle assembly checkpoint | nuclear chromosome segregation | negative regulation of mitotic sister chromatid segregation | negative regulation of mitotic sister chromatid separation | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | protein metabolic process | cellular macromolecule catabolic process | regulation of sister chromatid segregation | mitotic cell cycle | nuclear division | metabolic process | negative regulation of mitotic cell cycle | organic substance metabolic process | regulation of chromosome organization | mitotic nuclear division | attachment of spindle microtubules to kinetochore | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of mitotic sister chromatid segregation | meiotic cell cycle | negative regulation of chromosome organization | cellular protein metabolic process | organelle organization | regulation of mitotic metaphase/anaphase transition | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | modification-dependent protein catabolic process | cell cycle checkpoint | mitotic sister chromatid segregation | regulation of cellular component organization | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | condensed chromosome kinetochore | membrane-bounded organelle | nucleus | organelle | mitotic checkpoint complex | membrane-enclosed lumen | bub1-bub3 complex | cytosol | intracellular | condensed chromosome