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QuickView for C3 (gene)


Gene Symbol:
C3 Homo sapiens Homo sapiens
Full name:
complement C3
Synonyms:
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3a anaphylatoxin, acylation-stimulating protein cleavage product, complement component 3, complement component C3a, complement component C3b, epididymis secretory sperm binding protein Li 62p, prepro-C3
Genomic Location:
Chr 19: 6628846-6671662
Description:
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numero...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.3


Transcripts Names
NM_000064
Protein Names
A7E236
V9HWA9
P01024
B4DR57



GO Molecular Function

endopeptidase inhibitor activity | C5a anaphylatoxin chemotactic receptor binding | enzyme inhibitor activity | signaling receptor binding | hydrolase activity | molecular function regulator | catalytic activity | serine hydrolase activity | C5L2 anaphylatoxin chemotactic receptor binding | protein binding | G-protein coupled receptor binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase inhibitor activity | enzyme regulator activity | peptidase activity

GO Biological Process

positive regulation of immune response | adaptive immune response | endopeptidase inhibitor activity | exocytosis | positive regulation of cellular component organization | neutrophil activation | proteolysis | phagocytosis, engulfment | regulation of localization | complement activation | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | defense response | positive regulation of phosphate metabolic process | membrane organization | negative regulation of proteolysis | cellular process | secretion | leukocyte degranulation | localization | positive regulation of immune effector process | positive regulation of adaptive immune response | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | positive regulation of apoptotic cell clearance | regulation of angiogenesis | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | cellular lipid metabolic process | positive regulation of protein processing | regulation of vasculature development | response to stimulus | enzyme inhibitor activity | monocarboxylic acid metabolic process | neutrophil degranulation | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | positive regulation of activation of membrane attack complex | leukocyte activation involved in immune response | regulation of humoral immune response | positive regulation of vascular endothelial growth factor production | secretion by cell | positive regulation of proteolysis | regulation of phagocytosis | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | protein modification process | regulation of protein processing | regulation of triglyceride metabolic process | macromolecule modification | regulation of lipid storage | molecular function regulator | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of catalytic activity | regulation of peptidase activity | positive regulation of inflammatory response | leukocyte mediated immunity | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | negative regulation of peptidase activity | regulation of acute inflammatory response | regulation of gene expression | complement activation, alternative pathway | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of type IIa hypersensitivity | regulation of nitrogen compound metabolic process | small molecule metabolic process | amyloid-beta clearance | vesicle-mediated transport | positive regulation of humoral immune response | positive regulation of lipid storage | positive regulation of hypersensitivity | positive regulation of glucose transmembrane transport | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | positive regulation of acute inflammatory response to antigenic stimulus | regulated exocytosis | protein activation cascade | positive regulation of lipid localization | regulation of complement activation | response to bacterium | cell communication | regulation of cellular metabolic process | humoral immune response | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of protein phosphorylation | positive regulation of transport | regulation of lipid biosynthetic process | regulation of apoptotic cell clearance | carboxylic acid metabolic process | activation of immune response | protein metabolic process | positive regulation of protein modification process | import into cell | complement activation, classical pathway | metabolic process | regulation of adaptive immune response | positive regulation of inflammatory response to antigenic stimulus | membrane invagination | regulation of vesicle-mediated transport | positive regulation of complement activation | endocytosis | immune response | organic substance metabolic process | positive regulation of acute inflammatory response | regulation of glucose transmembrane transport | negative regulation of cellular protein metabolic process | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of phagocytosis | serine-type endopeptidase activity | regulation of phosphate metabolic process | serine-type peptidase activity | fatty acid metabolic process | positive regulation of cytokine production | cell activation | negative regulation of protein metabolic process | regulation of cell communication | humoral immune response mediated by circulating immunoglobulin | positive regulation of protein maturation | negative regulation of molecular function | signaling | endopeptidase activity | regulation of endocytosis | organic acid metabolic process | positive regulation of phosphorylation | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | regulation of endopeptidase activity | response to biotic stimulus | regulation of developmental process | B cell mediated immunity | regulation of G-protein coupled receptor protein signaling pathway | cellular protein modification process | regulation of transport | innate immune response | neutrophil mediated immunity | regulation of vascular endothelial growth factor production | negative regulation of hydrolase activity | regulation of lipid metabolic process | positive regulation of metabolic process | immunoglobulin mediated immune response | immune system process | cellular metabolic process | peptidase activity | regulation of inflammatory response | phagocytosis | positive regulation of endocytosis | positive regulation of angiogenesis | regulation of triglyceride biosynthetic process | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | post-translational protein modification | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | vacuole | vesicle | endoplasmic reticulum lumen | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | lysosome | extracellular space | cell periphery | membrane-enclosed lumen | azurophil granule | secretory granule lumen | blood microparticle | intracellular vesicle | intracellular | membrane | vesicle lumen