Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for C4A (gene)


Gene Symbol:
C4A Homo sapiens Homo sapiens
Full name:
complement C4A (Rodgers blood group)
Synonyms:
C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, complement C4-A, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A anaphylatoxin, MHC class III region complement, Rodgers form of C4, acidic C4, acidic complement C4, complement component 4A (Rodgers blood group)
Genomic Location:
Chr 6: 32090549-32111173
Description:
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other comp...
Orthologs:
Mus musculus Rattus norvegicus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6p21.33





GO Molecular Function

endopeptidase inhibitor activity | opsonin binding | complement binding | enzyme inhibitor activity | hydrolase activity | molecular function regulator | catalytic activity | complement component C1q binding | serine hydrolase activity | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase inhibitor activity | enzyme regulator activity | peptidase activity

GO Biological Process

positive regulation of immune response | adaptive immune response | endopeptidase inhibitor activity | positive regulation of cellular component organization | proteolysis | regulation of localization | complement activation | regulation of immune system process | negative regulation of cellular process | defense response | negative regulation of proteolysis | cellular process | regulation of proteolysis | negative regulation of cellular metabolic process | positive regulation of apoptotic cell clearance | regulation of immune response | regulation of cellular process | regulation of metabolic process | response to stimulus | enzyme inhibitor activity | positive regulation of immune system process | response to stress | regulation of humoral immune response | regulation of phagocytosis | negative regulation of metabolic process | protein modification process | regulation of protein processing | macromolecule modification | molecular function regulator | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | nitrogen compound metabolic process | negative regulation of catalytic activity | regulation of peptidase activity | leukocyte mediated immunity | regulation of catalytic activity | negative regulation of peptidase activity | regulation of acute inflammatory response | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of cellular protein metabolic process | protein activation cascade | regulation of complement activation | regulation of cellular metabolic process | humoral immune response | inflammatory response | regulation of protein metabolic process | positive regulation of transport | regulation of apoptotic cell clearance | activation of immune response | protein metabolic process | complement activation, classical pathway | metabolic process | regulation of vesicle-mediated transport | immune response | organic substance metabolic process | negative regulation of cellular protein metabolic process | positive regulation of phagocytosis | serine-type endopeptidase activity | serine-type peptidase activity | negative regulation of protein metabolic process | humoral immune response mediated by circulating immunoglobulin | negative regulation of molecular function | endopeptidase activity | regulation of endocytosis | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | regulation of endopeptidase activity | B cell mediated immunity | cellular protein modification process | regulation of transport | innate immune response | negative regulation of hydrolase activity | immunoglobulin mediated immune response | immune system process | cellular metabolic process | peptidase activity | regulation of inflammatory response | positive regulation of endocytosis | regulation of cellular component organization | negative regulation of endopeptidase activity | post-translational protein modification | macromolecule metabolic process

GO Cellular Component

dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | cell projection | endomembrane system | plasma membrane | vesicle | endoplasmic reticulum lumen | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | axon | membrane-enclosed lumen | blood microparticle | intracellular | cell junction | membrane