QuickView for C5 (gene)

Gene Symbol:

C5 Homo sapiens

Full name:

complement C5

Synonyms:

C5D, C5a, C5b, CPAMD4, ECLZB, complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5a anaphylatoxin, anaphylatoxin C5a analog, complement component 5, prepro-C5

Genomic Location:

Chr 9: 122754434-122852375

Description:

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin an...

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This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  HNF3ALPHA_Q6 ,  TTANTCA_UNKNOWN ,  WTGAAAT_UNKNOWN ,  GCTTGAA_MIR498 ,  PAX4_02 ,  YY1_01 ,  TGTTTGY_HNF3_Q6 ,  TAATTA_CHX10_01 ,  BRN2_01 ,  TGACATY_UNKNOWN ,  CRX_Q4 ,  HNF1_Q6

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Cytogenetic Map:

9q33.2

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