QuickView for C8A (gene)

Gene Symbol:

C8A Homo sapiens

Full name:

complement C8 alpha chain

Synonyms:

complement component C8 alpha chain, complement component 8 alpha subunit, complement component 8 subunit alpha, complement component 8, alpha polypeptide

Genomic Location:

Chr 1: 57093065-57156482

Description:

C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene...

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C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FXR_Q3 ,  HOXA4_Q2 ,  IPF1_Q4 ,  HNF1_C ,  TATAAA_TATA_01 ,  GGATTA_PITX2_Q2 ,  HNF4_Q6 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  CTTTGT_LEF1_Q2 ,  HNF1_Q6

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Cytogenetic Map:

1p32.2

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