QuickView for CAP37 (gene)

Gene Symbol:

AZU1 Homo sapiens

Full name:

azurocidin 1

Synonyms:

AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC, hHBP, azurocidin, cationic antimicrobial protein 37, cationic antimicrobial protein CAP37, heparin-binding protein, neutrophil azurocidin

Genomic Location:

Chr 19: 778831-783017

Description:

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunct...

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Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

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Orthologs:

Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

19p13.3

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