QuickView for CARS1 (gene)

Gene Symbol:

CARS Homo sapiens

Full name:

cysteinyl-tRNA synthetase

Synonyms:

CARS1, CYSRS, MGC:11246, cysteine--tRNA ligase, cytoplasmic, cysteine tRNA ligase 1, cytoplasmic, cysteine translase

Genomic Location:

Chr 11: 2978735-3035247

Description:

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppress...

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This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

EFC_Q6 ,  MIF1_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  RFX1_01 ,  OCT1_06 ,  CHOP_01 ,  SCGGAAGY_ELK1_02

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-30

Cytogenetic Map:

11p15.4

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