QuickView for CASC4;jsessionid=84B4E06B9402E9557B3AF064FC651387 (gene)

Gene Symbol:

CASC4 Homo sapiens

Full name:

cancer susceptibility 4

Synonyms:

H63, protein CASC4, cancer susceptibility candidate 4, cancer susceptibility candidate gene 4 protein, gene associated with HER-2/neu overexpression

Genomic Location:

Chr 15: 42368221-42495247

Description:

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene.

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXJ2_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  CTTTGCA_MIR527 ,  AREB6_04 ,  ATGTACA_MIR493 ,  WTGAAAT_UNKNOWN ,  TITF1_Q3 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  AP4_01 ,  TGCCTTA_MIR124A ,  E47_01 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  GTTNYYNNGGTNA_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

15q15.3

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