QuickView for CBFB (gene)

Gene Symbol:

CBFB Homo sapiens

Full name:

core-binding factor beta subunit

Synonyms:

PEBP2B, core-binding factor subunit beta, CBF-beta, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, polyomavirus enhancer binding protein 2, beta subunit

Genomic Location:

Chr 16: 65620551-65692462

Description:

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically en...

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The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  MAZR_01 ,  TTTTGAG_MIR373 ,  AACTGAC_MIR223 ,  CTATGCA_MIR153 ,  AACTGGA_MIR145 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TACTTGA_MIR26A_MIR26B ,  FAC1_01 ,  ACTGTGA_MIR27A_MIR27B ,  ATGCTGG_MIR338 ,  RRAGTTGT_UNKNOWN ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  TGTTTGY_HNF3_Q6 ,  NRF1_Q6 ,  TTGTTT_FOXO4_01 ,  GTTATAT_MIR410 ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  BRN2_01 ,  TCATCTC_MIR143 ,  GGCKCATGS_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

16q22.1

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