QuickView for CBX2 (gene)

Gene Symbol:

CBX2 Homo sapiens

Full name:

chromobox 2

Synonyms:

CDCA6, M33, SRXY5, chromobox protein homolog 2, Pc class homolog, cell division cycle associated 6, chromobox homolog 2 (Pc class homolog, Drosophila), modifier 3

Genomic Location:

Chr 17: 75366588-75375974

Description:

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associate...

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This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGNNNNNNKCCAR_UNKNOWN ,  FOXO4_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  NFKAPPAB_01 ,  GGATTA_PITX2_Q2 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GACAATC_MIR219 ,  GTGCCTT_MIR506 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  ZF5_B ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  CACTTTG_MIR520G_MIR520H

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Cytogenetic Map:

17q25.3

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