QuickView for CBX5 (gene)
- Gene Symbol:
- CBX5
Homo sapiens - Full name:
- chromobox 5
- Synonyms:
- HEL25, HP1, HP1A, chromobox protein homolog 5, HP1 alpha homolog, HP1-ALPHA, HP1Hs alpha, antigen p25, chromobox homolog 5 (HP1 alpha homolog, Drosophila), epididymis luminal protein 25, heterochromatin protein 1 homolog alpha, heterochromatin protein 1-alpha
- Genomic Location:
- Chr 12: 52921677-52960151
- Description:
-
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (C...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q13.13
GO Molecular Function
repressing transcription factor binding | enzyme binding | protein-containing complex binding | methylated histone binding | chromatin binding | ribonucleoprotein complex binding | protein binding, bridging | modification-dependent protein binding | identical protein binding | molecular adaptor activity | protein binding | protein homodimerization activity | transcription factor binding | protein dimerization activity | histone binding | histone deacetylase binding
GO Biological Process
regulation of cell cycle process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cellular process | negative regulation of nucleic acid-templated transcription | hemostasis | regulation of cell cycle | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of cellular process | regulation of metabolic process | response to stimulus | response to stress | negative regulation of metabolic process | blood coagulation | regulation of nucleic acid-templated transcription | cellular response to DNA damage stimulus | wound healing | regulation of gene expression | cellular response to stress | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | negative regulation of G0 to G1 transition | regulation of cellular metabolic process | regulation of RNA metabolic process | viral process | coagulation | response to wounding | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of G0 to G1 transition | negative regulation of cell cycle | regulation of transcription, DNA-templated | negative regulation of transcription by RNA polymerase II | negative regulation of cell cycle process | multicellular organismal process
GO Cellular Component
site of DNA damage | chromosome | intracellular membrane-bounded organelle | catalytic complex | chromosome, centromeric region | cell | nuclear lumen | kinetochore | nucleolus | intracellular organelle | nuclear body | histone methyltransferase complex | chromocenter | protein-containing complex | PML body | methyltransferase complex | endomembrane system | histone deacetylase complex | nucleoplasm | nuclear envelope | chromatin | nuclear chromosome | ribonucleoprotein complex | transferase complex | pericentric heterochromatin | chromosome, telomeric region | membrane-bounded organelle | transcriptional repressor complex | heterochromatin | nucleus | organelle | nuclear heterochromatin | membrane-enclosed lumen | nuclear chromatin | nuclear chromosome, telomeric region | intracellular | nuclear pericentric heterochromatin
