QuickView for CCL21 (gene)

Gene Symbol:

CCL21 Homo sapiens

Full name:

C-C motif chemokine ligand 21

Synonyms:

6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine 21, Efficient Chemoattractant for Lymphocytes, beta chemokine exodus-2, chemokine (C-C motif) ligand 21, secondary lymphoid tissue chemokine, small inducible cytokine subfamily A (Cys-Cys), member 21

Genomic Location:

Chr 9: 34699002-34700147

Description:

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoie...

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This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCTGG_MIR338 ,  CAGNWMCNNNGAC_UNKNOWN ,  CAGCAGG_MIR370

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-370

Cytogenetic Map:

9p13.3

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