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QuickView for CCND1;jsessionid=EFEE269348D4C1B01EDB982124632C1D (gene)


Gene Symbol:
CCND1 Homo sapiens Homo sapiens
Full name:
cyclin D1
Synonyms:
BCL1, D11S287E, PRAD1, U21B31, G1/S-specific cyclin-D1, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene
Genomic Location:
Chr 11: 69165054-69178423
Description:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
OCT1_07 NFMUE1_Q6 RTAAACA_FREAC2_01 TFIIA_Q6 STAT1_02 OCT1_04 OCT1_01 HOXA4_Q2 YATGNWAAT_OCT_C YTATTTTNR_MEF2_02
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 11
11q13.3


Transcripts Names
NM_053056
Protein Names
P24385
Q6FI00
Q6LEF0



GO Molecular Function

kinase binding | protein kinase regulator activity | kinase regulator activity | protein kinase binding | enzyme binding | protein-containing complex binding | cyclin-dependent protein kinase activity | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | proline-rich region binding | transcription corepressor activity | protein binding | transcription factor binding | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | enzyme regulator activity | kinase activity | histone deacetylase binding | transcription coregulator activity | cyclin-dependent protein serine/threonine kinase regulator activity

GO Biological Process

positive regulation of cyclin-dependent protein serine/threonine kinase activity | RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | DNA-templated transcription, initiation | response to radiation | regulation of cell cycle process | response to nutrient levels | response to endoplasmic reticulum stress | response to cytokine | developmental process involved in reproduction | regulation of cell cycle G1/S phase transition | protein kinase regulator activity | gonad development | positive regulation of G1/S transition of mitotic cell cycle | response to X-ray | establishment of localization | response to hormone | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | positive regulation of epithelial cell proliferation | response to drug | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | regulation of organelle organization | response to antibiotic | cellular process | secretion | Leydig cell differentiation | response to magnesium ion | localization | mitotic DNA integrity checkpoint | negative regulation of signaling | negative regulation of G1/S transition of mitotic cell cycle | kinase regulator activity | reproductive system development | canonical Wnt signaling pathway | response to estradiol | regulation of mitotic nuclear division | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | endoplasmic reticulum unfolded protein response | response to corticosterone | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell cycle arrest | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regeneration | regulation of cellular process | regulation of metabolic process | hepaticobiliary system development | positive regulation of cyclin-dependent protein kinase activity | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular response to topologically incorrect protein | development of primary sexual characteristics | response to UV | response to stimulus | cyclin-dependent protein kinase activity | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of mammary gland epithelial cell proliferation | regulation of cell cycle phase transition | regulation of epithelial cell differentiation | protein serine/threonine kinase activity | positive regulation of mammary gland epithelial cell proliferation | reproduction | response to alcohol | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | cellular biosynthetic process | response to iron ion | macromolecule modification | cell-cell signaling | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | response to ethanol | regulation of nucleic acid-templated transcription | response to nitrogen compound | regulation of cell cycle G2/M phase transition | response to light stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | Wnt signaling pathway | mitotic DNA damage checkpoint | multicellular organism development | response to UV-A | phosphorus metabolic process | mammary gland development | response to vitamin E | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | mammary gland lobule development | positive regulation of mitotic cell cycle | regulation of gene expression | response to ketone | cellular response to stress | response to lipid | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | liver development | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | response to corticosteroid | transcription corepressor activity | regulation of transcription by RNA polymerase II | response to nutrient | positive regulation of cell cycle G2/M phase transition | fat cell differentiation | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | cell division | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | mammary gland epithelial cell proliferation | response to toxic substance | mitotic cell cycle phase transition | positive regulation of cell cycle G1/S phase transition | protein phosphorylation | phosphate-containing compound metabolic process | mitotic G1 DNA damage checkpoint | response to estrogen | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | liver regeneration | regulation of protein metabolic process | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of mitotic cell cycle | negative regulation of epithelial cell differentiation | positive regulation of molecular function | development of primary male sexual characteristics | protein metabolic process | positive regulation of protein modification process | response to organic substance | gland development | G1 DNA damage checkpoint | epithelial cell proliferation | lactation | regulation of kinase activity | male sex differentiation | cyclin-dependent protein serine/threonine kinase activity | response to leptin | anatomical structure development | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | response to mineralocorticoid | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | male gonad development | negative regulation of mitotic cell cycle | body fluid secretion | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of kinase activity | re-entry into mitotic cell cycle | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | mammary gland epithelium development | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | mammary gland alveolus development | negative regulation of cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | response to unfolded protein | cellular macromolecule biosynthetic process | reproductive structure development | regulation of developmental process | kinase activity | developmental process | positive regulation of cell cycle process | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | response to organonitrogen compound | cell cycle phase transition | transcription coregulator activity | heterocycle metabolic process | response to calcium ion | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | sex differentiation | response to steroid hormone | DNA damage checkpoint | cell cycle checkpoint | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | signal transduction | regulation of signaling | animal organ regeneration | response to glucocorticoid | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

occluding junction | intracellular membrane-bounded organelle | catalytic complex | protein kinase complex | cell | nuclear lumen | cytoplasm | intracellular organelle | cell-cell junction | protein-containing complex | nucleoplasm | transferase complex | serine/threonine protein kinase complex | membrane-bounded organelle | transcriptional repressor complex | apical junction complex | nucleus | organelle | bicellular tight junction | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | cytosol | intracellular | cell junction | membrane