QuickView for CD14 (gene)
- Gene Symbol:
- CD14
Homo sapiens - Full name:
- CD14 molecule
- Synonyms:
- monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
- Genomic Location:
- Chr 5: 139991501-139993439
- Description:
-
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q31.3
GO Molecular Function
peptide binding | transmembrane signaling receptor activity | lipoteichoic acid binding | lipid binding | carbohydrate derivative binding | peptidoglycan receptor activity | amide binding | signaling receptor activity | lipopeptide binding | signaling pattern recognition receptor activity | protein binding | lipopolysaccharide binding | opsonin receptor activity
GO Biological Process
positive regulation of immune response | negative regulation of immune system process | exocytosis | response to cytokine | positive regulation of cellular component organization | immune response-regulating signaling pathway | neutrophil activation | response to lipopolysaccharide | intracellular signal transduction | cellular response to diacyl bacterial lipopeptide | negative regulation of MyD88-independent toll-like receptor signaling pathway | regulation of localization | necroptotic process | establishment of localization | regulation of immune system process | negative regulation of cellular process | response to metal ion | defense response | response to drug | positive regulation of protein secretion | response to antibiotic | innate immune response-activating signal transduction | cellular process | secretion | toll-like receptor signaling pathway | leukocyte degranulation | response to magnesium ion | localization | cellular response to bacterial lipopeptide | negative regulation of signaling | programmed necrotic cell death | regulation of MyD88-independent toll-like receptor signaling pathway | response to inorganic substance | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | negative regulation of toll-like receptor signaling pathway | positive regulation of tumor necrosis factor production | regulation of peptide secretion | regulation of type I interferon production | cellular response to triacyl bacterial lipopeptide | response to stimulus | positive regulation of NIK/NF-kappaB signaling | regulation of interleukin-8 secretion | neutrophil degranulation | positive regulation of innate immune response | positive regulation of immune system process | response to stress | leukocyte activation involved in immune response | programmed cell death | toll-like receptor TLR6:TLR2 signaling pathway | activation of innate immune response | secretion by cell | response to alcohol | positive regulation of cytokine secretion | response to temperature stimulus | response to molecule of bacterial origin | immune response-activating signal transduction | regulation of protein transport | regulation of peptide transport | response to ethanol | positive regulation of peptide secretion | apoptotic process | peptidoglycan receptor activity | response to external biotic stimulus | regulation of signal transduction | pattern recognition receptor signaling pathway | regulation of toll-like receptor signaling pathway | leukocyte mediated immunity | positive regulation of secretion | response to lipid | positive regulation of intracellular signal transduction | vesicle-mediated transport | TRIF-dependent toll-like receptor signaling pathway | regulated exocytosis | response to toxic substance | regulation of tumor necrosis factor production | response to bacterium | cell communication | signaling pattern recognition receptor activity | inflammatory response | cell activation involved in immune response | regulation of NIK/NF-kappaB signaling | myeloid cell activation involved in immune response | positive regulation of signal transduction | neutrophil activation involved in immune response | positive regulation of establishment of protein localization | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | apoptotic signaling pathway | regulation of cytokine secretion | activation of immune response | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | MyD88-independent toll-like receptor signaling pathway | import into cell | regulation of intracellular signal transduction | cellular response to lipoteichoic acid | cell surface receptor signaling pathway | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | toll-like receptor 4 signaling pathway | immune response | positive regulation of interleukin-8 secretion | cell death | response to bacterial lipoprotein | regulation of protein secretion | response to heat | toll-like receptor TLR1:TLR2 signaling pathway | positive regulation of cytokine production | cell activation | positive regulation of protein transport | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of endocytosis | I-kappaB kinase/NF-kappaB signaling | regulation of cytokine production | response to biotic stimulus | receptor-mediated endocytosis | regulation of transport | necrotic cell death | innate immune response | MyD88-dependent toll-like receptor signaling pathway | neutrophil mediated immunity | response to electrical stimulus | regulation of interferon-gamma production | immune system process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | positive regulation of type I interferon production | phagocytosis | positive regulation of endocytosis | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to lipopolysaccharide
GO Cellular Component
secretory granule | integral component of membrane | intracellular membrane-bounded organelle | intrinsic component of external side of plasma membrane | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | anchored component of plasma membrane | secretory granule membrane | endosome membrane | Golgi apparatus | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | membrane raft | vesicle | extracellular exosome | anchored component of membrane | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | anchored component of external side of plasma membrane | extracellular space | cell periphery | intracellular vesicle | cell surface | lipopolysaccharide receptor complex | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane
