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QuickView for CD278 (gene)


Gene Symbol:
ICOS Homo sapiens Homo sapiens
Full name:
inducible T cell costimulator
Synonyms:
AILIM, CD278, CVID1, inducible T-cell costimulator, activation-inducible lymphocyte immunomediatory molecule, inducible T-cell co-stimulator, inducible costimulator
Genomic Location:
Chr 2: 204509748-204534545
Description:
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Gallus gallus Bos taurus Pan troglodytes
External Links:
Entrez Gene
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 2
2q33.2


Transcripts Names
NM_012092
Protein Names
Q8N6W8
Q9Y6W8
Q53QY6



GO Molecular Function

catalytic activity | phosphatidylinositol 3-kinase activity | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | transferase activity | kinase activity

GO Biological Process

phosphatidylinositol metabolic process | regulation of immune system process | positive regulation of lymphocyte activation | lymphocyte costimulation | positive regulation of cell adhesion | phospholipid metabolic process | cellular process | tolerance induction | immune system development | regulation of protein kinase B signaling | regulation of cellular process | cellular lipid metabolic process | response to stimulus | positive regulation of immune system process | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | regulation of cell adhesion | system development | regulation of signal transduction | multicellular organism development | phosphorus metabolic process | positive regulation of protein kinase B signaling | lipid metabolic process | regulation of T cell activation | organophosphate metabolic process | regulation of lymphocyte activation | positive regulation of intracellular signal transduction | phosphatidylinositol 3-kinase activity | phosphorylation | T cell tolerance induction | phosphate-containing compound metabolic process | lipid phosphorylation | positive regulation of signal transduction | lipid modification | glycerolipid metabolic process | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | regulation of intracellular signal transduction | anatomical structure development | metabolic process | positive regulation of leukocyte activation | cell adhesion | immune response | organic substance metabolic process | regulation of cell activation | cell-cell adhesion | T cell costimulation | regulation of cell communication | phosphatidylinositol phosphorylation | glycerophospholipid metabolic process | kinase activity | developmental process | regulation of cell-cell adhesion | immune system process | cellular metabolic process | positive regulation of leukocyte cell-cell adhesion | positive regulation of signaling | regulation of signaling | multicellular organismal process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | plasma membrane | integral component of plasma membrane | extracellular region | cell periphery | cell surface | membrane | intrinsic component of plasma membrane