QuickView for CD44 (gene)

Gene Symbol:

CD44 Homo sapiens

Full name:

CD44 molecule (Indian blood group)

Synonyms:

CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 antigen, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, epican, extracellular matrix receptor III, hematopoietic cell E- and L-selectin ligand, heparan sulfate proteoglycan, homing function and Indian blood group system, hyaluronate receptor, phagocytic glycoprotein 1, soluble CD44

Genomic Location:

Chr 11: 35116993-35210525

Description:

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions i...

View Full Description

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  MIF1_01 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  GGGYGTGNY_UNKNOWN ,  GAGCTGG_MIR337 ,  NRF2_Q4 ,  MYB_Q6 ,  YNGTTNNNATT_UNKNOWN ,  TGASTMAGC_NFE2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-381

miRNA binding sites
(Source: miRecords):

hsa-miR-373 Targeted Genes ,  [miR-520c] Targeted Genes

Cytogenetic Map:

11p13

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