QuickView for CD45 (gene)
- Gene Symbol:
- PTPRC
Homo sapiens - Full name:
- protein tyrosine phosphatase, receptor type C
- Synonyms:
- B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, receptor-type tyrosine-protein phosphatase C, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide
- Genomic Location:
- Chr 1: 196874760-196993168
- Description:
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem ...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
PAX4_04 , RYTTCCTG_ETS2_B , PEA3_Q6 , GATAAGR_GATA_C , PBX1_01 , TGAYRTCA_ATF3_Q6 , PXR_Q2 , EVI1_02 , NKX25_02 , CART1_01
- Cytogenetic Map:
-
1q31.3-q32.1
| Transcripts Names |
|---|
| NM_002838 |
| NM_080921 |
| NM_080922 |
| NM_080923 |
| NM_001267798 |
| NR_052021 |
| XM_006711472 |
| XM_006711474 |
| XM_006711473 |
GO Molecular Function
kinase binding | proteoglycan binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | phosphatase activity | hydrolase activity | carbohydrate derivative binding | protein tyrosine phosphatase activity | catalytic activity | anion binding | phosphoprotein phosphatase activity | signaling receptor activity | hydrolase activity, acting on ester bonds | identical protein binding | ion binding | heparin binding | heparan sulfate proteoglycan binding | protein binding | transmembrane receptor protein tyrosine phosphatase activity | phosphoric ester hydrolase activity | glycosaminoglycan binding
GO Biological Process
positive regulation of immune response | positive regulation of cell killing | regulation of T cell mediated immunity | negative regulation of phosphorylation | response to radiation | positive regulation of locomotion | response to virus | negative regulation of immune system process | exocytosis | protein dephosphorylation | regulation of B cell activation | cell motility | immune response-regulating signaling pathway | neutrophil activation | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | cytosolic calcium ion transport | regulation of localization | regulation of programmed cell death | defense response to other organism | heterotypic cell-cell adhesion | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | bone development | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | regulation of T cell mediated cytotoxicity | T cell receptor signaling pathway | defense response | negative regulation of protein phosphorylation | cellular chemical homeostasis | positive regulation of DNA recombination | regulation of leukocyte mediated cytotoxicity | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | negative regulation of T cell mediated cytotoxicity | B cell differentiation | negative T cell selection | regulation of isotype switching to IgG isotypes | positive regulation of T cell differentiation | cellular process | secretion | lymphocyte differentiation | leukocyte degranulation | regulation of cell motility | localization | cellular homeostasis | positive regulation of humoral immune response mediated by circulating immunoglobulin | negative regulation of signaling | metal ion transport | positive regulation of immune effector process | positive regulation of adaptive immune response | immune system development | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | positive regulation of hematopoietic stem cell migration | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | negative regulation of protein autophosphorylation | negative thymic T cell selection | calcium ion homeostasis | T cell activation | phosphatase activity | calcium ion transport into cytosol | response to stimulus | positive regulation of antigen receptor-mediated signaling pathway | regulation of DNA recombination | neutrophil degranulation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | mononuclear cell proliferation | positive regulation of immunoglobulin production | response to stress | leukocyte activation involved in immune response | negative regulation of protein kinase activity | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | regulation of humoral immune response mediated by circulating immunoglobulin | positive regulation of B cell proliferation | hematopoietic progenitor cell differentiation | regulation of humoral immune response | positive regulation of cell activation | cellular localization | divalent metal ion transport | secretion by cell | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | hemopoiesis | protein modification process | regulation of cell adhesion | macromolecule modification | protein tyrosine phosphatase activity | B cell receptor signaling pathway | activation of protein kinase activity | metal ion homeostasis | regulation of lymphocyte differentiation | immunoglobulin biosynthetic process | negative regulation of adaptive immune response | leukocyte differentiation | locomotion | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cell migration | positive regulation of lymphocyte differentiation | calcium ion transmembrane transport | regulation of MAPK cascade | phosphorus metabolic process | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | ion transmembrane transport | positive regulation of gamma-delta T cell differentiation | regulation of T cell activation | regulation of extrinsic apoptotic signaling pathway | positive thymic T cell selection | cell cycle | regulation of protein autophosphorylation | regulation of stem cell proliferation | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | cellular ion homeostasis | phosphoprotein phosphatase activity | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | vesicle-mediated transport | positive regulation of humoral immune response | regulation of cellular component movement | positive regulation of cell differentiation | stem cell differentiation | positive regulation of cell migration | B cell activation | cell proliferation | leukocyte proliferation | biosynthetic process | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | positive regulation of T cell proliferation | regulation of gamma-delta T cell differentiation | negative regulation of immune response | regulated exocytosis | regulation of apoptotic signaling pathway | positive regulation of isotype switching | response to gamma radiation | cation homeostasis | phosphate-containing compound metabolic process | negative regulation of cell adhesion involved in substrate-bound cell migration | cellular cation homeostasis | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | positive regulation of B cell activation | lymphocyte activation | positive regulation of molecular function | release of sequestered calcium ion into cytosol | activation of MAPK activity | cation transmembrane transport | T cell differentiation | activation of immune response | protein metabolic process | positive regulation of protein modification process | T cell selection | T cell differentiation in thymus | regulation of hemopoiesis | transmembrane receptor protein tyrosine phosphatase activity | regulation of kinase activity | regulation of intracellular signal transduction | substrate-dependent cell migration | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | leukocyte cell-cell adhesion | metabolic process | regulation of isotype switching | bone marrow development | immunoglobulin production | regulation of adaptive immune response | positive regulation of leukocyte activation | positive T cell selection | chemical homeostasis | calcium ion transport | positive regulation of cell death | cell adhesion | immune response | thymic T cell selection | organic substance metabolic process | regulation of B cell differentiation | regulation of sequestering of calcium ion | positive regulation of T cell mediated cytotoxicity | animal organ development | negative regulation of cellular protein metabolic process | T cell proliferation | regulation of cell activation | positive regulation of programmed cell death | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | inorganic cation transmembrane transport | antigen receptor-mediated signaling pathway | negative regulation of T cell mediated immunity | cell-cell adhesion | cell activation | positive regulation of MAPK cascade | positive regulation of T cell mediated immunity | stem cell development | negative regulation of protein metabolic process | lymphocyte proliferation | regulation of cell communication | dephosphorylation | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | regulation of immunoglobulin production | cell development | negative regulation of peptidyl-tyrosine phosphorylation | regulation of T cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | cation transport | positive regulation of stem cell proliferation | positive regulation of MAP kinase activity | response to biotic stimulus | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | positive regulation of alpha-beta T cell activation | cellular protein modification process | B cell proliferation | regulation of B cell proliferation | peptidyl-tyrosine dephosphorylation | regulation of cell-cell adhesion | positive regulation of leukocyte mediated cytotoxicity | neutrophil mediated immunity | cell cycle phase transition | cellular metal ion homeostasis | regulation of B cell receptor signaling pathway | negative regulation of cytokine-mediated signaling pathway | positive regulation of isotype switching to IgG isotypes | positive regulation of metabolic process | ion transport | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of cell death | positive regulation of cell motility | divalent inorganic cation homeostasis | positive regulation of leukocyte cell-cell adhesion | response to ionizing radiation | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gamma-delta T cell activation | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | integral component of membrane | adherens junction | organelle membrane | focal adhesion | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | cell-substrate junction | intracellular organelle | membrane microdomain | secretory granule membrane | secretory vesicle | endomembrane system | plasma membrane | membrane raft | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | extracellular space | cell periphery | cell-substrate adherens junction | intracellular vesicle | cell surface | intracellular | cell junction | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane
