QuickView for CD53 (gene)

Gene Symbol:

CD53 Homo sapiens

Full name:

CD53 molecule

Synonyms:

MOX44, TSPAN25, leukocyte surface antigen CD53, CD53 antigen, CD53 glycoprotein, CD53 tetraspan antigen, antigen MOX44 identified by monoclonal antibody MRC-OX44, cell surface antigen, cell surface glycoprotein CD53, tetraspanin-25, transmembrane glycoprotein, tspan-25

Genomic Location:

Chr 1: 111215344-111244081

Description:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,...

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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PEA3_Q6 ,  IRF1_Q6 ,  MGGAAGTG_GABP_B ,  RNGTGGGC_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-361

Cytogenetic Map:

1p13.3

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