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QuickView for CD80 (gene)


Gene Symbol:
CD80 Homo sapiens Homo sapiens
Full name:
CD80 molecule
Synonyms:
B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, B-lymphocyte activation antigen B7, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CTLA-4 counter-receptor B7.1, activation B7-1 antigen, costimulatory factor CD80, costimulatory molecule variant IgV-CD80
Genomic Location:
Chr 3: 120725830-120761171
Description:
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Bos taurus Pan troglodytes Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 3
3q13.33


Transcripts Names
NM_005191
XM_011513327
XM_017007520
Protein Names
A0N0P2
P33681



GO Molecular Function

coreceptor activity | catalytic activity | signaling receptor activity | phosphatidylinositol 3-kinase activity | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | virus receptor activity | transferase activity | kinase activity

GO Biological Process

positive regulation of immune response | negative regulation of leukocyte activation | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | response to cytokine | response to lipopolysaccharide | intracellular signal transduction | positive regulation of peptidyl-tyrosine phosphorylation | phosphatidylinositol metabolic process | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of T cell differentiation | lymphocyte costimulation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | phospholipid metabolic process | positive regulation of T cell differentiation | positive regulation of cellular biosynthetic process | cellular process | regulation of cytokine biosynthetic process | positive regulation of immune effector process | positive regulation of adaptive immune response | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | regulation of cell differentiation | interspecies interaction between organisms | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | negative regulation of mononuclear cell proliferation | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | entry into host cell | cellular lipid metabolic process | viral life cycle | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | response to molecule of bacterial origin | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | positive regulation of T cell activation | positive regulation of RNA biosynthetic process | regulation of cell adhesion | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | regulation of interleukin-2 biosynthetic process | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | regulation of signal transduction | positive regulation of lymphocyte differentiation | phosphorus metabolic process | positive regulation of protein kinase B signaling | lipid metabolic process | regulation of phosphorylation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | viral entry into host cell | response to lipid | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | positive regulation of interleukin-2 biosynthetic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | phosphatidylinositol 3-kinase activity | positive regulation of cell differentiation | cellular response to cytokine stimulus | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | phosphorylation | phosphate-containing compound metabolic process | lipid phosphorylation | response to bacterium | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | lipid modification | positive regulation of cell proliferation | regulation of protein phosphorylation | glycerolipid metabolic process | regulation of RNA metabolic process | viral process | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | positive regulation of T-helper cell differentiation | positive regulation of protein modification process | response to organic substance | regulation of hemopoiesis | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | regulation of adaptive immune response | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | immune response | organic substance metabolic process | positive regulation of T-helper 1 type immune response | virus receptor activity | positive regulation of T-helper 1 cell differentiation | regulation of cell activation | regulation of phosphate metabolic process | positive regulation of cytokine production | regulation of T-helper cell differentiation | T cell costimulation | regulation of cell communication | regulation of T-helper 1 cell differentiation | signaling | regulation of transcription, DNA-templated | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | positive regulation of phosphorylation | regulation of cytokine production | phosphatidylinositol phosphorylation | response to biotic stimulus | regulation of developmental process | glycerophospholipid metabolic process | kinase activity | positive regulation of alpha-beta T cell activation | positive regulation of interleukin-2 production | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of metabolic process | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | cellular response to organic substance | positive regulation of CD4-positive, alpha-beta T cell activation | positive regulation of leukocyte cell-cell adhesion | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | protein-containing complex | plasma membrane | cell periphery | protein complex involved in cell adhesion | cell surface | intracellular | membrane