QuickView for CDC27Hs (gene)

Gene Symbol:

CDC27 Homo sapiens

Full name:

cell division cycle 27

Synonyms:

ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2, cell division cycle protein 27 homolog, D0S1430E, D17S978E, anaphase promoting complex subunit 3, anaphase-promoting complex, protein 3, cell division cycle 27 homolog, nuc2 homolog

Genomic Location:

Chr 17: 42552625-42621664

Description:

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the forma...

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The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CRGAARNNNNCGA_UNKNOWN ,  CMYB_01 ,  MAZR_01 ,  DR3_Q4 ,  GATA1_01 ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  LYF1_01 ,  CACCCBINDINGFACTOR_Q6 ,  GATA2_01 ,  HMGIY_Q6 ,  TTGCCAA_MIR182 ,  PAX5_01 ,  GGCAGTG_MIR3243P ,  RRCCGTTA_UNKNOWN ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

17q21.32

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