QuickView for CDK4I (gene)
- Gene Symbol:
- Cdkn2a
Mus musculus - Full name:
- cyclin-dependent kinase inhibitor 2A
- Synonyms:
- ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF, cyclin-dependent kinase inhibitor 2A, CDK4I, alternative reading frame, cdkn2a, cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4), cyclin-dependent kinase inhibitor 2A, isoforms 1/2, cyclin-dependent kinase inhibitor protein, mitochondrial smARF, p16-INK4, p16-INK4a
- Genomic Location:
- Chr 4: 88920377-88940523
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
kinase binding | protein kinase regulator activity | NF-kappaB binding | protein serine/threonine kinase inhibitor activity | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | nucleic acid binding | disordered domain specific binding | enzyme inhibitor activity | ubiquitin-protein transferase inhibitor activity | molecular function regulator | catalytic activity | protein domain specific binding | protein N-terminus binding | ubiquitin-like protein transferase activity | p53 binding | ubiquitin ligase inhibitor activity | DNA binding | MDM2/MDM4 family protein binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | transcription factor binding | kinase inhibitor activity | transferase activity | enzyme regulator activity | SUMO transferase activity | ubiquitin-protein transferase regulator activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | heterocyclic compound binding | cyclin-dependent protein serine/threonine kinase regulator activity
GO Biological Process
negative regulation of lymphocyte differentiation | RNA metabolic process | negative regulation of leukocyte activation | positive regulation of myeloid cell apoptotic process | negative regulation of phosphorylation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | negative regulation of immune system process | positive regulation of cell aging | RNA processing | regulation of B cell activation | regulation of cellular localization | positive regulation of apoptotic process | protein stabilization | regulation of localization | protein kinase regulator activity | positive regulation of DNA-binding transcription factor activity | somatic stem cell population maintenance | regulation of programmed cell death | peptidyl-amino acid modification | regulation of cell aging | regulation of immune system process | regulation of immature T cell proliferation in thymus | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | negative regulation of RNA biosynthetic process | regulation of T cell differentiation | protein serine/threonine kinase inhibitor activity | negative regulation of cell-matrix adhesion | negative regulation of B cell proliferation | response to drug | protein sumoylation | negative regulation of protein phosphorylation | glucose homeostasis | regulation of organelle organization | response to antibiotic | negative regulation of proteolysis | autophagy of mitochondrion | positive regulation of cellular biosynthetic process | cellular process | positive regulation of signal transduction by p53 class mediator | protein K63-linked ubiquitination | negative regulation of ubiquitin-dependent protein catabolic process | chromatin organization | regulation of ubiquitin-protein transferase activity | regulation of DNA damage response, signal transduction by p53 class mediator | regulation of mitochondrial membrane potential | kinase regulator activity | protein kinase inhibitor activity | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | regulation of proteolysis | regulation of hepatocyte proliferation | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | negative regulation of T cell proliferation | positive regulation of muscle cell apoptotic process | response to inorganic substance | regulation of protein export from nucleus | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | senescence-associated heterochromatin focus assembly | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of ubiquitin-protein transferase activity | catabolic process | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | positive regulation of response to DNA damage stimulus | negative regulation of cellular protein catabolic process | response to stimulus | enzyme inhibitor activity | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of cellular protein catabolic process | negative regulation of cell adhesion | positive regulation of smooth muscle cell apoptotic process | response to stress | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of protein ubiquitination | regulation of mammary gland epithelial cell proliferation | positive regulation of cysteine-type endopeptidase activity | regulation of cell cycle phase transition | ncRNA processing | programmed cell death | protein destabilization | supramolecular fiber organization | positive regulation of mammary gland involution | positive regulation of proteolysis | cellular nitrogen compound metabolic process | cellular response to toxic substance | cell cycle G1/S phase transition | apoptotic mitochondrial changes | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | negative regulation of hemopoiesis | protein modification process | ubiquitin-protein transferase inhibitor activity | regulation of peptide transport | negative regulation of immature T cell proliferation | regulation of cell adhesion | cellular biosynthetic process | mitochondrion organization | macromolecule modification | regulation of intracellular transport | molecular function regulator | regulation of lymphocyte differentiation | mitochondrial depolarization | regulation of nucleic acid-templated transcription | somatic stem cell division | regulation of membrane potential | negative regulation of NF-kappaB transcription factor activity | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | regulation of cell cycle G2/M phase transition | heterochromatin organization | regulation of macrophage apoptotic process | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | regulation of protein stability | negative regulation of phosphate metabolic process | cellular response to antibiotic | negative regulation of catalytic activity | regulation of peptidase activity | positive regulation of protein sumoylation | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | negative regulation of hepatocyte proliferation | cellular response to oxidative stress | regulation of phosphorylation | positive regulation of DNA damage response, signal transduction by p53 class mediator | amyloid fibril formation | ncRNA transcription | regulation of T cell activation | positive regulation of cell cycle | regulation of gene expression | cellular response to stress | cell cycle | negative regulation of cyclin-dependent protein serine/threonine kinase activity | stem cell division | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of protein localization to nucleus | ubiquitin ligase inhibitor activity | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of T cell activation | regulation of cell-substrate adhesion | regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | regulation of transcription by RNA polymerase II | regulation of smooth muscle cell apoptotic process | response to oxidative stress | rRNA transcription | negative regulation of binding | positive regulation of hydrolase activity | negative regulation of mammary gland epithelial cell proliferation | negative regulation of immature T cell proliferation in thymus | positive regulation of protein localization to nucleus | biosynthetic process | cell division | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of cell-substrate adhesion | negative regulation of protein neddylation | positive regulation of endopeptidase activity | epidermis development | response to toxic substance | positive regulation of leukocyte apoptotic process | rRNA metabolic process | negative regulation of ubiquitin protein ligase activity | mitotic cell cycle phase transition | regulation of protein sumoylation | regulation of apoptotic DNA fragmentation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | autophagy | cellular response to drug | regulation of mitochondrion organization | negative regulation of cell-cell adhesion | regulation of muscle cell apoptotic process | negative regulation of protein binding | regulation of cellular metabolic process | chromatin remodeling | regulation of protein kinase activity | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | G1/S transition of mitotic cell cycle | regulation of protein phosphorylation | regulation of RNA metabolic process | negative regulation of protein ubiquitination | negative regulation of cell growth | rRNA processing | cell aging | positive regulation of apoptotic process involved in development | negative regulation of T cell differentiation | negative regulation of B cell activation | regulation of mitotic cell cycle | organelle disassembly | positive regulation of molecular function | regulation of nucleocytoplasmic transport | protein polyubiquitination | positive regulation of cell cycle arrest | negative regulation of cyclin-dependent protein kinase activity | negative regulation of epithelial cell proliferation | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | protein ubiquitination | regulation of hemopoiesis | cell cycle arrest | kinase inhibitor activity | regulation of kinase activity | regulation of animal organ morphogenesis | replicative senescence | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | chromatin assembly or disassembly | anatomical structure development | mitotic cell cycle | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of protein catabolic process | regulation of protein targeting | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of tissue remodeling | peptidyl-lysine modification | cellular response to hydrogen peroxide | chemical homeostasis | positive regulation of cell death | membrane depolarization | regulation of myeloid cell apoptotic process | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | maintenance of cell number | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | response to reactive oxygen species | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | positive regulation of programmed cell death | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | DNA packaging | transcription, DNA-templated | chromatin assembly | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | positive regulation of macrophage apoptotic process | regulation of cell communication | negative regulation of molecular function | cellular senescence | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | regulation of T cell proliferation | regulation of epithelial cell proliferation | regulation of T cell differentiation in thymus | cellular protein metabolic process | enzyme regulator activity | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | SUMO transferase activity | positive regulation of tissue remodeling | regulation of developmental process | positive regulation of cellular senescence | developmental process | organelle organization | ubiquitin-protein transferase regulator activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | positive regulation of cell cycle process | regulation of cell growth | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | DNA conformation change | response to organonitrogen compound | cell cycle phase transition | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of apoptotic process involved in development | positive regulation of metabolic process | chromosome organization | positive regulation of apoptotic process involved in mammary gland involution | ribonucleoprotein complex biogenesis | regulation of execution phase of apoptosis | negative regulation of lymphocyte proliferation | cellular metabolic process | positive regulation of apoptotic process involved in morphogenesis | regulation of protein localization | regulation of cell death | heterochromatin assembly | aging | carbohydrate homeostasis | regulation of ubiquitin-dependent protein catabolic process | negative regulation of T cell differentiation in thymus | negative regulation of proteolysis involved in cellular protein catabolic process | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | regulation of cell-matrix adhesion | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | regulation of cellular senescence | multicellular organismal process | regulation of protein targeting to mitochondrion | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | senescence-associated heterochromatin focus | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | chromatin | mitochondrion | granular component | membrane-bounded organelle | heterochromatin | nucleus | organelle | membrane-enclosed lumen | intracellular
