QuickView for CDK5R1;jsessionid=96F0662CAA6F6637C4A32FF7D84E8831 (gene)

Gene Symbol:

CDK5R1 Homo sapiens

Full name:

cyclin dependent kinase 5 regulatory subunit 1

Synonyms:

CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5 activator 1, CDK5 activator 1, TPKII regulatory subunit, neuronal CDK5 activator, regulatory partner for CDK5 kinase, tau protein kinase II 23kDa subunit

Genomic Location:

Chr 17: 27838218-27842384

Description:

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the p...

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The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  GTGCCAT_MIR183 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  ATF4_Q2 ,  ARP1_01 ,  GTACTGT_MIR101 ,  ARNT_02 ,  GGTGAAG_MIR412 ,  NRSF_01 ,  MYCMAX_02 ,  LEF1_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  SP1_Q4_01 ,  ZID_01 ,  ATGCTGC_MIR103_MIR107 ,  CAGNWMCNNNGAC_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  AP2_Q3 ,  SP1_Q6 ,  HSF2_01 ,  AATGTGA_MIR23A_MIR23B ,  YGCGYRCGC_UNKNOWN ,  CAAGGAT_MIR362 ,  CTTTGT_LEF1_Q2 ,  SP1_Q6_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  HNF4_01_B ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-499

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Cytogenetic Map:

17q11.2

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