QuickView for CEase (gene)

Gene Symbol:

CEL Homo sapiens

Full name:

carboxyl ester lipase

Synonyms:

BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8, bile salt-activated lipase, bile salt-dependent lipase, oncofetal isoform, bucelipase, carboxyl ester hydrolase, carboxyl ester lipase (bile salt-stimulated lipase), cholesterol esterase, fetoacinar pancreatic protein, lysophospholipase, pancreatic, sterol esterase

Genomic Location:

Chr 9: 134927186-134937069

Description:

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. ...

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The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGACCTY_ERR1_Q2 ,  CAGGTG_E12_Q6 ,  E47_02 ,  AREB6_01 ,  AREB6_03 ,  TGACCTTG_SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-485-5p

Cytogenetic Map:

9q34.13

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