QuickView for CHD4 (gene)
- Gene Symbol:
- CHD4
Homo sapiens - Full name:
- chromodomain helicase DNA binding protein 4
- Synonyms:
- CHD-4, Mi-2b, Mi2-BETA, SIHIWES, chromodomain-helicase-DNA-binding protein 4, ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein
- Genomic Location:
- Chr 12: 6549509-6586812
- Description:
-
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with sero...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CTTGTAT_MIR381 , PAX4_04 , TFIIA_Q6 , MCAATNNNNNGCG_UNKNOWN , MAZR_01 , USF_Q6 , ARNT_01 , MYC_Q2 , HEN1_01 , SYATTGTG_UNKNOWN
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12p13.31
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | enhancer binding | cation binding | repressing transcription factor binding | nucleosome binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | ATP-dependent DNA helicase activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | protein deacetylase activity | catalytic activity | chromatin binding | ATP binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | anion binding | adenyl nucleotide binding | enhancer sequence-specific DNA binding | histone deacetylase activity | RNA polymerase II repressing transcription factor binding | nucleoside-triphosphatase activity | RNA polymerase II regulatory region DNA binding | ATPase activity, coupled | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | nucleosomal DNA binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | purine ribonucleoside triphosphate binding | DNA helicase activity | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | chromatin DNA binding | RNA polymerase II transcription factor binding | hydrolase activity, acting on acid anhydrides | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transition metal ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | deacetylase activity | DNA-dependent ATPase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | helicase activity | drug binding | histone deacetylase binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
RNA metabolic process | histone modification | histone deacetylation | cellular process | chromatin organization | DNA geometric change | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | ATP-dependent DNA helicase activity | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | protein modification process | protein deacetylase activity | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | ATP-dependent chromatin remodeling | regulation of gene expression | histone deacetylase activity | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | protein deacetylation | aromatic compound biosynthetic process | DNA duplex unwinding | regulation of cellular metabolic process | chromatin remodeling | regulation of RNA metabolic process | DNA helicase activity | protein metabolic process | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | organelle organization | cellular protein modification process | DNA conformation change | heterocycle metabolic process | chromosome organization | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | cell | nuclear lumen | nuclear transcriptional repressor complex | cytoplasm | intracellular organelle | centrosome | protein-containing complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | microtubule cytoskeleton | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | SWI/SNF superfamily-type complex | NuRD complex | membrane-enclosed lumen | nuclear chromatin | ATPase complex | cytoskeleton | intracellular | membrane
