QuickView for CHFR;jsessionid=FA902B44B6859B06376DB8A60F248A89 (gene)

Gene Symbol:

CHFR Homo sapiens

Full name:

checkpoint with forkhead and ring finger domains

Synonyms:

RNF116, RNF196, E3 ubiquitin-protein ligase CHFR, RING finger protein 196, RING-type E3 ubiquitin transferase CHFR, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

Genomic Location:

Chr 12: 131927011-131974257

Description:

This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-...

View Full Description

This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  ACTGTAG_MIR139 ,  TACTTGA_MIR26A_MIR26B ,  YY1_Q6 ,  GCTCTTG_MIR335 ,  WTTGKCTG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-488 ,  Predicted Gene Targets for miR-378

Cytogenetic Map:

12q24.33

search → result