QuickView for CHGA (gene)

Gene Symbol:

CHGA Homo sapiens

Full name:

chromogranin A

Synonyms:

CGA, chromogranin-A, SP-I, betagranin (N-terminal fragment of chromogranin A), catestatin, chromofungin, parathyroid secretory protein 1, pituitary secretory protein I

Genomic Location:

Chr 14: 92459198-92471391

Description:

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine ...

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The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGA_LEF1_Q2 ,  TGACCTY_ERR1_Q2 ,  NRSF_01 ,  CAGNWMCNNNGAC_UNKNOWN ,  NF1_Q6 ,  CATRRAGC_UNKNOWN ,  NF1_Q6_01 ,  TTGTTT_FOXO4_01 ,  CTGCAGY_UNKNOWN ,  TGACCTTG_SF1_Q6 ,  SF1_Q6 ,  MYB_Q3

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Cytogenetic Map:

14q32.12

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